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Page 1
Neurobiological Effects of Morphine after Spinal Cord Injury.
Hook MA, Woller SA, Bancroft E, Aceves M, Funk MK, Hartman J, Garraway SM. Hook MA, et al. J Neurotrauma. 2017 Feb;34(3):632-644. doi: 10.1089/neu.2016.4507. Epub 2016 Nov 2. J Neurotrauma. 2017. PMID: 27762659 Free PMC article.
Aficamten is a small-molecule cardiac myosin inhibitor designed to treat hypertrophic cardiomyopathy.
Hartman JJ, Hwee DT, Robert-Paganin J, Chuang C, Chin ER, Edell S, Lee KH, Madhvani R, Paliwal P, Pernier J, Sarkar SS, Schaletzky J, Schauer K, Taheri KD, Wang J, Wehri E, Wu Y, Houdusse A, Morgan BP, Malik FI. Hartman JJ, et al. Nat Cardiovasc Res. 2024 Aug;3(8):1003-1016. doi: 10.1038/s44161-024-00505-0. Epub 2024 Jul 23. Nat Cardiovasc Res. 2024. PMID: 39196032 Free PMC article.
Super-relaxed myosins contribute to respiratory muscle hibernation in mechanically ventilated patients.
van den Berg M, Shi Z, Claassen WJ, Hooijman P, Lewis CTA, Andersen JL, van der Pijl RJ, Bogaards SJP, Conijn S, Peters EL, Begthel LPL, Uijterwijk B, Lindqvist J, Langlais PR, Girbes ARJ, Stapel S, Granzier H, Campbell KS, Ma W, Irving T, Hwee DT, Hartman JJ, Malik FI, Paul M, Beishuizen A, Ochala J, Heunks L, Ottenheijm CAC. van den Berg M, et al. Among authors: hartman jj. Sci Transl Med. 2024 Jul 31;16(758):eadg3894. doi: 10.1126/scitranslmed.adg3894. Epub 2024 Jul 31. Sci Transl Med. 2024. PMID: 39083588
Pathogenic TNNI1 variants disrupt sarcomere contractility resulting in hypo- and hypercontractile muscle disease.
Donkervoort S, van de Locht M, Ronchi D, Reunert J, McLean CA, Zaki M, Orbach R, de Winter JM, Conijn S, Hoomoedt D, Neto OLA, Magri F, Viaene AN, Foley AR, Gorokhova S, Bolduc V, Hu Y, Acquaye N, Napoli L, Park JH, Immadisetty K, Miles LB, Essawi M, McModie S, Ferreira LF, Zanotti S, Neuhaus SB, Medne L, ElBagoury N, Johnson KR, Zhang Y, Laing NG, Davis MR, Bryson-Richardson RJ, Hwee DT, Hartman JJ, Malik FI, Kekenes-Huskey PM, Comi GP, Sharaf-Eldin W, Marquardt T, Ravenscroft G, Bönnemann CG, Ottenheijm CAC. Donkervoort S, et al. Among authors: hartman jj. Sci Transl Med. 2024 Apr 3;16(741):eadg2841. doi: 10.1126/scitranslmed.adg2841. Epub 2024 Apr 3. Sci Transl Med. 2024. PMID: 38569017 Free article.
Cardiac Troponin Activator CK-963 Increases Cardiac Contractility in Rats.
Collibee SE, Romero A, Muci AR, Hwee DT, Chuang C, Hartman JJ, Motani AS, Ashcraft L, DeRosier A, Grillo M, Lu Q, Malik FI, Morgan BP. Collibee SE, et al. Among authors: hartman jj. J Med Chem. 2024 May 23;67(10):7859-7869. doi: 10.1021/acs.jmedchem.3c02412. Epub 2024 Mar 7. J Med Chem. 2024. PMID: 38451215 Free PMC article.
Titin-truncating variants in hiPSC cardiomyocytes induce pathogenic proteinopathy and sarcomere defects with preserved core contractile machinery.
Huang G, Bisaria A, Wakefield DL, Yamawaki TM, Luo X, Zhang JA, Vigneault P, Wang J, Reagan JD, Oliverio O, Zhou H, Li CM, Vila OF, Wang S, Malik FI, Hartman JJ, Hale CM. Huang G, et al. Among authors: hartman jj. Stem Cell Reports. 2023 Jan 10;18(1):220-236. doi: 10.1016/j.stemcr.2022.11.008. Epub 2022 Dec 15. Stem Cell Reports. 2023. PMID: 36525964 Free PMC article.
50 results