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Reversal of diet-induced hepatic steatosis and hepatic insulin resistance by antisense oligonucleotide inhibitors of acetyl-CoA carboxylases 1 and 2.
Savage DB, Choi CS, Samuel VT, Liu ZX, Zhang D, Wang A, Zhang XM, Cline GW, Yu XX, Geisler JG, Bhanot S, Monia BP, Shulman GI. Savage DB, et al. Among authors: zhang xm, zhang d. J Clin Invest. 2006 Mar;116(3):817-24. doi: 10.1172/JCI27300. Epub 2006 Feb 16. J Clin Invest. 2006. PMID: 16485039 Free PMC article.
Suppression of diacylglycerol acyltransferase-2 (DGAT2), but not DGAT1, with antisense oligonucleotides reverses diet-induced hepatic steatosis and insulin resistance.
Choi CS, Savage DB, Kulkarni A, Yu XX, Liu ZX, Morino K, Kim S, Distefano A, Samuel VT, Neschen S, Zhang D, Wang A, Zhang XM, Kahn M, Cline GW, Pandey SK, Geisler JG, Bhanot S, Monia BP, Shulman GI. Choi CS, et al. Among authors: zhang xm, zhang d. J Biol Chem. 2007 Aug 3;282(31):22678-88. doi: 10.1074/jbc.M704213200. Epub 2007 May 27. J Biol Chem. 2007. PMID: 17526931 Free article.
Apolipoprotein C3 gene variants in nonalcoholic fatty liver disease.
Petersen KF, Dufour S, Hariri A, Nelson-Williams C, Foo JN, Zhang XM, Dziura J, Lifton RP, Shulman GI. Petersen KF, et al. Among authors: zhang xm. N Engl J Med. 2010 Mar 25;362(12):1082-9. doi: 10.1056/NEJMoa0907295. N Engl J Med. 2010. PMID: 20335584 Free PMC article.
A high-fat, ketogenic diet causes hepatic insulin resistance in mice, despite increasing energy expenditure and preventing weight gain.
Jornayvaz FR, Jurczak MJ, Lee HY, Birkenfeld AL, Frederick DW, Zhang D, Zhang XM, Samuel VT, Shulman GI. Jornayvaz FR, et al. Among authors: zhang xm, zhang d. Am J Physiol Endocrinol Metab. 2010 Nov;299(5):E808-15. doi: 10.1152/ajpendo.00361.2010. Epub 2010 Aug 31. Am J Physiol Endocrinol Metab. 2010. PMID: 20807839 Free PMC article.
Fatty acid amide hydrolase ablation promotes ectopic lipid storage and insulin resistance due to centrally mediated hypothyroidism.
Brown WH, Gillum MP, Lee HY, Camporez JP, Zhang XM, Jeong JK, Alves TC, Erion DM, Guigni BA, Kahn M, Samuel VT, Cravatt BF, Diano S, Shulman GI. Brown WH, et al. Among authors: zhang xm. Proc Natl Acad Sci U S A. 2012 Sep 11;109(37):14966-71. doi: 10.1073/pnas.1212887109. Epub 2012 Aug 21. Proc Natl Acad Sci U S A. 2012. PMID: 22912404 Free PMC article.
2,796 results