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Disturbed mitochondrial dynamics in CD8+ TILs reinforce T cell exhaustion.
Yu YR, Imrichova H, Wang H, Chao T, Xiao Z, Gao M, Rincon-Restrepo M, Franco F, Genolet R, Cheng WC, Jandus C, Coukos G, Jiang YF, Locasale JW, Zippelius A, Liu PS, Tang L, Bock C, Vannini N, Ho PC. Yu YR, et al. Among authors: tang l. Nat Immunol. 2020 Dec;21(12):1540-1551. doi: 10.1038/s41590-020-0793-3. Epub 2020 Oct 5. Nat Immunol. 2020. PMID: 33020660
Synthetic 3D scaffolds for cancer immunotherapy.
Kurum A, Gao M, Tang L. Kurum A, et al. Among authors: tang l. Curr Opin Biotechnol. 2020 Oct;65:1-8. doi: 10.1016/j.copbio.2019.11.010. Epub 2019 Dec 13. Curr Opin Biotechnol. 2020. PMID: 31838435 Review.
Metabolic reprogramming of terminally exhausted CD8+ T cells by IL-10 enhances anti-tumor immunity.
Guo Y, Xie YQ, Gao M, Zhao Y, Franco F, Wenes M, Siddiqui I, Bevilacqua A, Wang H, Yang H, Feng B, Xie X, Sabatel CM, Tschumi B, Chaiboonchoe A, Wang Y, Li W, Xiao W, Held W, Romero P, Ho PC, Tang L. Guo Y, et al. Among authors: tang l. Nat Immunol. 2021 Jun;22(6):746-756. doi: 10.1038/s41590-021-00940-2. Epub 2021 May 24. Nat Immunol. 2021. PMID: 34031618 Free PMC article.
Cancer-cell stiffening via cholesterol depletion enhances adoptive T-cell immunotherapy.
Lei K, Kurum A, Kaynak M, Bonati L, Han Y, Cencen V, Gao M, Xie YQ, Guo Y, Hannebelle MTM, Wu Y, Zhou G, Guo M, Fantner GE, Sakar MS, Tang L. Lei K, et al. Among authors: tang l. Nat Biomed Eng. 2021 Dec;5(12):1411-1425. doi: 10.1038/s41551-021-00826-6. Epub 2021 Dec 6. Nat Biomed Eng. 2021. PMID: 34873307 Free PMC article.
The type 2 cytokine Fc-IL-4 revitalizes exhausted CD8+ T cells against cancer.
Feng B, Bai Z, Zhou X, Zhao Y, Xie YQ, Huang X, Liu Y, Enbar T, Li R, Wang Y, Gao M, Bonati L, Peng MW, Li W, Tao B, Charmoy M, Held W, Melenhorst JJ, Fan R, Guo Y, Tang L. Feng B, et al. Among authors: tang l. Nature. 2024 Oct;634(8034):712-720. doi: 10.1038/s41586-024-07962-4. Epub 2024 Sep 25. Nature. 2024. PMID: 39322665 Free PMC article.
Single-cell CAR T atlas reveals type 2 function in 8-year leukaemia remission.
Bai Z, Feng B, McClory SE, de Oliveira BC, Diorio C, Gregoire C, Tao B, Yang L, Zhao Z, Peng L, Sferruzza G, Zhou L, Zhou X, Kerr J, Baysoy A, Su G, Yang M, Camara PG, Chen S, Tang L, June CH, Melenhorst JJ, Grupp SA, Fan R. Bai Z, et al. Among authors: tang l. Nature. 2024 Oct;634(8034):702-711. doi: 10.1038/s41586-024-07762-w. Epub 2024 Sep 25. Nature. 2024. PMID: 39322664 Free PMC article.
Microfluidic T Cell Selection by Cellular Avidity.
Ashby JF, Schmidt J, Kc N, Kurum A, Koch C, Harari A, Tang L, Au SH. Ashby JF, et al. Among authors: tang l. Adv Healthc Mater. 2022 Aug;11(16):e2200169. doi: 10.1002/adhm.202200169. Epub 2022 Jun 21. Adv Healthc Mater. 2022. PMID: 35657072 Free PMC article.
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