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Associating HIV-1 envelope glycoprotein structures with states on the virus observed by smFRET.
Lu M, Ma X, Castillo-Menendez LR, Gorman J, Alsahafi N, Ermel U, Terry DS, Chambers M, Peng D, Zhang B, Zhou T, Reichard N, Wang K, Grover JR, Carman BP, Gardner MR, Nikić-Spiegel I, Sugawara A, Arthos J, Lemke EA, Smith AB 3rd, Farzan M, Abrams C, Munro JB, McDermott AB, Finzi A, Kwong PD, Blanchard SC, Sodroski JG, Mothes W. Lu M, et al. Nature. 2019 Apr;568(7752):415-419. doi: 10.1038/s41586-019-1101-y. Epub 2019 Apr 10. Nature. 2019. PMID: 30971821 Free PMC article.
A New Family of Small-Molecule CD4-Mimetic Compounds Contacts Highly Conserved Aspartic Acid 368 of HIV-1 gp120 and Mediates Antibody-Dependent Cellular Cytotoxicity.
Ding S, Grenier MC, Tolbert WD, Vézina D, Sherburn R, Richard J, Prévost J, Chapleau JP, Gendron-Lepage G, Medjahed H, Abrams C, Sodroski J, Pazgier M, Smith AB 3rd, Finzi A. Ding S, et al. J Virol. 2019 Nov 26;93(24):e01325-19. doi: 10.1128/JVI.01325-19. Print 2019 Dec 15. J Virol. 2019. PMID: 31554684 Free PMC article.
Optimization of Small Molecules That Sensitize HIV-1 Infected Cells to Antibody-Dependent Cellular Cytotoxicity.
Grenier MC, Ding S, Vézina D, Chapleau JP, Tolbert WD, Sherburn R, Schön A, Somisetti S, Abrams CF, Pazgier M, Finzi A, Smith AB 3rd. Grenier MC, et al. Among authors: abrams cf. ACS Med Chem Lett. 2019 Nov 15;11(3):371-378. doi: 10.1021/acsmedchemlett.9b00445. eCollection 2020 Mar 12. ACS Med Chem Lett. 2019. PMID: 32184972 Free PMC article.
The HIV-1 Env gp120 Inner Domain Shapes the Phe43 Cavity and the CD4 Binding Site.
Prévost J, Tolbert WD, Medjahed H, Sherburn RT, Madani N, Zoubchenok D, Gendron-Lepage G, Gaffney AE, Grenier MC, Kirk S, Vergara N, Han C, Mann BT, Chénine AL, Ahmed A, Chaiken I, Kirchhoff F, Hahn BH, Haim H, Abrams CF, Smith AB 3rd, Sodroski J, Pazgier M, Finzi A. Prévost J, et al. Among authors: abrams cf. mBio. 2020 May 26;11(3):e00280-20. doi: 10.1128/mBio.00280-20. mBio. 2020. PMID: 32457241 Free PMC article.
Impact of temperature on the affinity of SARS-CoV-2 Spike glycoprotein for host ACE2.
Prévost J, Richard J, Gasser R, Ding S, Fage C, Anand SP, Adam D, Gupta Vergara N, Tauzin A, Benlarbi M, Gong SY, Goyette G, Privé A, Moreira S, Charest H, Roger M, Mothes W, Pazgier M, Brochiero E, Boivin G, Abrams CF, Schön A, Finzi A. Prévost J, et al. Among authors: abrams cf. J Biol Chem. 2021 Oct;297(4):101151. doi: 10.1016/j.jbc.2021.101151. Epub 2021 Aug 31. J Biol Chem. 2021. PMID: 34478710 Free PMC article.
VE607 stabilizes SARS-CoV-2 Spike in the "RBD-up" conformation and inhibits viral entry.
Ding S, Ullah I, Gong SY, Grover JR, Mohammadi M, Chen Y, Vézina D, Beaudoin-Bussières G, Verma VT, Goyette G, Gaudette F, Richard J, Yang D, Smith AB 3rd, Pazgier M, Côté M, Abrams C, Kumar P, Mothes W, Uchil PD, Finzi A, Baron C. Ding S, et al. iScience. 2022 Jul 15;25(7):104528. doi: 10.1016/j.isci.2022.104528. Epub 2022 Jun 3. iScience. 2022. PMID: 35677392 Free PMC article.
Structural and Functional Characterization of Indane-Core CD4-Mimetic Compounds Substituted with Heterocyclic Amines.
Chaplain C, Fritschi CJ, Anang S, Gong Z, Richard J, Bourassa C, Liang S, Mohammadi M, Park J, Finzi A, Madani N, Sodroski JG, Abrams CF, Hendrickson WA, Smith AB 3rd. Chaplain C, et al. Among authors: abrams cf. ACS Med Chem Lett. 2022 Dec 6;14(1):51-58. doi: 10.1021/acsmedchemlett.2c00376. eCollection 2023 Jan 12. ACS Med Chem Lett. 2022. PMID: 36655122 Free PMC article.
Indoline CD4-mimetic compounds mediate potent and broad HIV-1 inhibition and sensitization to antibody-dependent cellular cytotoxicity.
Fritschi CJ, Anang S, Gong Z, Mohammadi M, Richard J, Bourassa C, Severino KT, Richter H, Yang D, Chen HC, Chiu TJ, Seaman MS, Madani N, Abrams C, Finzi A, Hendrickson WA, Sodroski JG, Smith AB 3rd. Fritschi CJ, et al. Proc Natl Acad Sci U S A. 2023 Mar 28;120(13):e2222073120. doi: 10.1073/pnas.2222073120. Epub 2023 Mar 24. Proc Natl Acad Sci U S A. 2023. PMID: 36961924 Free PMC article.
96 results