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Phospholamban ablation rescues the enhanced propensity to arrhythmias of mice with CaMKII-constitutive phosphorylation of RyR2 at site S2814.
Mazzocchi G, Sommese L, Palomeque J, Felice JI, Di Carlo MN, Fainstein D, Gonzalez P, Contreras P, Skapura D, McCauley MD, Lascano EC, Negroni JA, Kranias EG, Wehrens XH, Valverde CA, Mattiazzi A. Mazzocchi G, et al. Among authors: valverde ca. J Physiol. 2016 Jun 1;594(11):3005-30. doi: 10.1113/JP271622. Epub 2016 Feb 2. J Physiol. 2016. PMID: 26695843 Free PMC article.
CaMKII-dependent phosphorylation of cardiac ryanodine receptors regulates cell death in cardiac ischemia/reperfusion injury.
Di Carlo MN, Said M, Ling H, Valverde CA, De Giusti VC, Sommese L, Palomeque J, Aiello EA, Skapura DG, Rinaldi G, Respress JL, Brown JH, Wehrens XH, Salas MA, Mattiazzi A. Di Carlo MN, et al. Among authors: valverde ca. J Mol Cell Cardiol. 2014 Sep;74:274-83. doi: 10.1016/j.yjmcc.2014.06.004. Epub 2014 Jun 17. J Mol Cell Cardiol. 2014. PMID: 24949568 Free PMC article.
Ablation of phospholamban rescues reperfusion arrhythmias but exacerbates myocardium infarction in hearts with Ca2+/calmodulin kinase II constitutive phosphorylation of ryanodine receptors.
Valverde CA, Mazzocchi G, Di Carlo MN, Ciocci Pardo A, Salas N, Ragone MI, Felice JI, Cely-Ortiz A, Consolini AE, Portiansky E, Mosca S, Kranias EG, Wehrens XHT, Mattiazzi A. Valverde CA, et al. Cardiovasc Res. 2019 Mar 1;115(3):556-569. doi: 10.1093/cvr/cvy213. Cardiovasc Res. 2019. PMID: 30169578 Free PMC article.
Increasing SR Ca uptake: a double-edged sword.
Valverde CA, Mattiazzi A. Valverde CA, et al. J Physiol. 2022 Mar;600(6):1533-1534. doi: 10.1113/JP282659. Epub 2022 Feb 3. J Physiol. 2022. PMID: 35001395 Free article. No abstract available.
66 results