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Structural basis for AcrVA4 inhibition of specific CRISPR-Cas12a.
Knott GJ, Cress BF, Liu JJ, Thornton BW, Lew RJ, Al-Shayeb B, Rosenberg DJ, Hammel M, Adler BA, Lobba MJ, Xu M, Arkin AP, Fellmann C, Doudna JA. Knott GJ, et al. Among authors: rosenberg dj. Elife. 2019 Aug 9;8:e49110. doi: 10.7554/eLife.49110. Elife. 2019. PMID: 31397669 Free PMC article.
A key interaction with RPA orients XPA in NER complexes.
Topolska-Woś AM, Sugitani N, Cordoba JJ, Le Meur KV, Le Meur RA, Kim HS, Yeo JE, Rosenberg D, Hammel M, Schärer OD, Chazin WJ. Topolska-Woś AM, et al. Nucleic Acids Res. 2020 Feb 28;48(4):2173-2188. doi: 10.1093/nar/gkz1231. Nucleic Acids Res. 2020. PMID: 31925419 Free PMC article.
Human XPG nuclease structure, assembly, and activities with insights for neurodegeneration and cancer from pathogenic mutations.
Tsutakawa SE, Sarker AH, Ng C, Arvai AS, Shin DS, Shih B, Jiang S, Thwin AC, Tsai MS, Willcox A, Her MZ, Trego KS, Raetz AG, Rosenberg D, Bacolla A, Hammel M, Griffith JD, Cooper PK, Tainer JA. Tsutakawa SE, et al. Proc Natl Acad Sci U S A. 2020 Jun 23;117(25):14127-14138. doi: 10.1073/pnas.1921311117. Epub 2020 Jun 10. Proc Natl Acad Sci U S A. 2020. PMID: 32522879 Free PMC article.
54 results