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Experimental Human Pneumococcal Colonization in Older Adults Is Feasible and Safe, Not Immunogenic.
Adler H, German EL, Mitsi E, Nikolaou E, Pojar S, Hales C, Robinson R, Connor V, Hill H, Hyder-Wright AD, Lazarova L, Lowe C, Smith EL, Wheeler I, Zaidi SR, Jochems SP, Loukov D, Reiné J, Solórzano-Gonzalez C, de Gorguette d'Argoeuves P, Jones T, Goldblatt D, Chen T, Aston SJ, French N, Collins AM, Gordon SB, Ferreira DM, Rylance J. Adler H, et al. Among authors: chen t. Am J Respir Crit Care Med. 2021 Mar 1;203(5):604-613. doi: 10.1164/rccm.202004-1483OC. Am J Respir Crit Care Med. 2021. PMID: 32941735 Free PMC article.
The nose is the best niche for detection of experimental pneumococcal colonisation in adults of all ages, using nasal wash.
Nikolaou E, German EL, Blizard A, Howard A, Hitchins L, Chen T, Chadwick J, Pojar S, Mitsi E, Solórzano C, Sunny S, Dunne F, Gritzfeld JF, Adler H, Hinds J, Gould KA, Rylance J, Collins AM, Gordon SB, Ferreira DM. Nikolaou E, et al. Among authors: chen t. Sci Rep. 2021 Sep 14;11(1):18279. doi: 10.1038/s41598-021-97807-1. Sci Rep. 2021. PMID: 34521967 Free PMC article.
Protocol for a phase IV double-blind randomised controlled trial to investigate the effect of the 13-valent pneumococcal conjugate vaccine and the 23-valent pneumococcal polysaccharide vaccine on pneumococcal colonisation using the experimental human pneumococcal challenge model in healthy adults (PREVENTING PNEUMO 2).
Liatsikos K, Hyder-Wright A, Pojar S, Chen T, Wang D, Davies K, Myerscough C, Reine J, Robinson RE, Urban B, Mitsi E, Solorzano C, Gordon SB, Quinn A, Pan K, Anderson AS, Theilacker C, Begier E, Gessner BD, Collins A, Ferreira DM; PNEUMO 2 study group. Liatsikos K, et al. Among authors: chen t. BMJ Open. 2022 Jul 7;12(7):e062109. doi: 10.1136/bmjopen-2022-062109. BMJ Open. 2022. PMID: 35798520 Free PMC article.
Human Infection Challenge with Serotype 3 Pneumococcus.
Robinson RE, Mitsi E, Nikolaou E, Pojar S, Chen T, Reiné J, Nyazika TK, Court J, Davies K, Farrar M, Gonzalez-Dias P, Hamilton J, Hill H, Hitchins L, Howard A, Hyder-Wright A, Lesosky M, Liatsikos K, Matope A, McLenaghan D, Myerscough C, Murphy A, Solórzano C, Wang D, Burhan H, Gautam M, Begier E, Theilacker C, Beavon R, Anderson AS, Gessner BD, Gordon SB, Collins AM, Ferreira DM. Robinson RE, et al. Among authors: chen t. Am J Respir Crit Care Med. 2022 Dec 1;206(11):1379-1392. doi: 10.1164/rccm.202112-2700OC. Am J Respir Crit Care Med. 2022. PMID: 35802840
Dolutegravir versus efavirenz in women starting HIV therapy in late pregnancy (DolPHIN-2): an open-label, randomised controlled trial.
Kintu K, Malaba TR, Nakibuka J, Papamichael C, Colbers A, Byrne K, Seden K, Hodel EM, Chen T, Twimukye A, Byamugisha J, Reynolds H, Watson V, Burger D, Wang D, Waitt C, Taegtmeyer M, Orrell C, Lamorde M, Myer L, Khoo S; DolPHIN-2 Study Group. Kintu K, et al. Among authors: chen t. Lancet HIV. 2020 May;7(5):e332-e339. doi: 10.1016/S2352-3018(20)30050-3. Lancet HIV. 2020. PMID: 32386721 Free PMC article. Clinical Trial.
Applicability and cost-effectiveness of the Systolic Blood Pressure Intervention Trial (SPRINT) in the Chinese population: A cost-effectiveness modeling study.
Li C, Chen K, Cornelius V, Tomeny E, Wang Y, Yang X, Yuan X, Qin R, Yu D, Wu Z, Wang D, Chen T. Li C, et al. Among authors: chen k, chen t. PLoS Med. 2021 Mar 4;18(3):e1003515. doi: 10.1371/journal.pmed.1003515. eCollection 2021 Mar. PLoS Med. 2021. PMID: 33661907 Free PMC article. Clinical Trial.
Factors associated with the prevalence of HIV, HSV-2, pregnancy, and reported sexual activity among adolescent girls in rural western Kenya: A cross-sectional analysis of baseline data in a cluster randomized controlled trial.
Zulaika G, Nyothach E, van Eijk AM, Obor D, Mason L, Wang D, Chen T, Kerubo E, Opollo V, Ngere I, Omondi Owino S, Oyaro B, Ter Kuile FO, Kwaro D, Phillips-Howard P. Zulaika G, et al. Among authors: chen t. PLoS Med. 2021 Sep 28;18(9):e1003756. doi: 10.1371/journal.pmed.1003756. eCollection 2021 Sep. PLoS Med. 2021. PMID: 34582445 Free PMC article. Clinical Trial.
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