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The MEK inhibitor selumetinib reduces spinal neurofibroma burden in patients with NF1 and plexiform neurofibromas.
Jackson S, Baker EH, Gross AM, Whitcomb P, Baldwin A, Derdak J, Tibery C, Desanto J, Carbonell A, Yohay K, O'Sullivan G, Chen AP, Widemann BC, Dombi E. Jackson S, et al. Among authors: gross am. Neurooncol Adv. 2020 Aug 8;2(1):vdaa095. doi: 10.1093/noajnl/vdaa095. eCollection 2020 Jan-Dec. Neurooncol Adv. 2020. PMID: 32939452 Free PMC article.
Selumetinib in Plexiform Neurofibromas.
Gross A, Bishop R, Widemann BC. Gross A, et al. N Engl J Med. 2017 Mar 23;376(12):1195. doi: 10.1056/NEJMc1701029. N Engl J Med. 2017. PMID: 28328340 No abstract available.
Advancing RAS/RASopathy therapies: An NCI-sponsored intramural and extramural collaboration for the study of RASopathies.
Gross AM, Frone M, Gripp KW, Gelb BD, Schoyer L, Schill L, Stronach B, Biesecker LG, Esposito D, Hernandez ER, Legius E, Loh ML, Martin S, Morrison DK, Rauen KA, Wolters PL, Zand D, McCormick F, Savage SA, Stewart DR, Widemann BC, Yohe ME. Gross AM, et al. Am J Med Genet A. 2020 Apr;182(4):866-876. doi: 10.1002/ajmg.a.61485. Epub 2020 Jan 8. Am J Med Genet A. 2020. PMID: 31913576 Free PMC article.
Selumetinib in Children with Inoperable Plexiform Neurofibromas.
Gross AM, Wolters PL, Dombi E, Baldwin A, Whitcomb P, Fisher MJ, Weiss B, Kim A, Bornhorst M, Shah AC, Martin S, Roderick MC, Pichard DC, Carbonell A, Paul SM, Therrien J, Kapustina O, Heisey K, Clapp DW, Zhang C, Peer CJ, Figg WD, Smith M, Glod J, Blakeley JO, Steinberg SM, Venzon DJ, Doyle LA, Widemann BC. Gross AM, et al. N Engl J Med. 2020 Apr 9;382(15):1430-1442. doi: 10.1056/NEJMoa1912735. Epub 2020 Mar 18. N Engl J Med. 2020. PMID: 32187457 Free PMC article. Clinical Trial.
A molecular basis for neurofibroma-associated skeletal manifestations in NF1.
Ma Y, Gross AM, Dombi E, Pemov A, Choi K, Chaney K, Rhodes SD, Angus SP, Sciaky N, Clapp DW, Ratner N, Widemann BC, Rios JJ, Elefteriou F. Ma Y, et al. Among authors: gross am. Genet Med. 2020 Nov;22(11):1786-1793. doi: 10.1038/s41436-020-0885-3. Epub 2020 Jun 30. Genet Med. 2020. PMID: 32601387 Free PMC article.
Are Some Randomized Clinical Trials Impossible?
Rios JJ, Richards BS, Stevenson DA, Oberlander B, Viskochil D, Gross AM, Dombi E, Widemann BC, Plotkin SR, May CJ, Ullrich NJ, Goldstein RY, Jain V, Schorry EK; NFCTC Consortium. Rios JJ, et al. Among authors: gross am. J Pediatr Orthop. 2021 Jan;41(1):e90-e93. doi: 10.1097/BPO.0000000000001650. J Pediatr Orthop. 2021. PMID: 32852366
149 results