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Page 1
Glucagon acutely regulates hepatic amino acid catabolism and the effect may be disturbed by steatosis.
Winther-Sørensen M, Galsgaard KD, Santos A, Trammell SAJ, Sulek K, Kuhre RE, Pedersen J, Andersen DB, Hassing AS, Dall M, Treebak JT, Gillum MP, Torekov SS, Windeløv JA, Hunt JE, Kjeldsen SAS, Jepsen SL, Vasilopoulou CG, Knop FK, Ørskov C, Werge MP, Bisgaard HC, Eriksen PL, Vilstrup H, Gluud LL, Holst JJ, Wewer Albrechtsen NJ. Winther-Sørensen M, et al. Mol Metab. 2020 Dec;42:101080. doi: 10.1016/j.molmet.2020.101080. Epub 2020 Sep 13. Mol Metab. 2020. PMID: 32937194 Free PMC article.
Why is it so difficult to measure glucagon-like peptide-1 in a mouse?
Windeløv JA, Wewer Albrechtsen NJ, Kuhre RE, Jepsen SL, Hornburg D, Pedersen J, Jensen EP, Galsgaard KD, Winther-Sørensen M, Ørgaard A, Deacon CF, Mann M, Kissow H, Hartmann B, Holst JJ. Windeløv JA, et al. Diabetologia. 2017 Oct;60(10):2066-2075. doi: 10.1007/s00125-017-4347-7. Epub 2017 Jul 1. Diabetologia. 2017. PMID: 28669086
Disruption of glucagon receptor signaling causes hyperaminoacidemia exposing a possible liver-alpha-cell axis.
Galsgaard KD, Winther-Sørensen M, Ørskov C, Kissow H, Poulsen SS, Vilstrup H, Prehn C, Adamski J, Jepsen SL, Hartmann B, Hunt J, Charron MJ, Pedersen J, Wewer Albrechtsen NJ, Holst JJ. Galsgaard KD, et al. Am J Physiol Endocrinol Metab. 2018 Jan 1;314(1):E93-E103. doi: 10.1152/ajpendo.00198.2017. Epub 2017 Oct 3. Am J Physiol Endocrinol Metab. 2018. PMID: 28978545 Free PMC article.
Circulating Glucagon 1-61 Regulates Blood Glucose by Increasing Insulin Secretion and Hepatic Glucose Production.
Wewer Albrechtsen NJ, Kuhre RE, Hornburg D, Jensen CZ, Hornum M, Dirksen C, Svane M, Gasbjerg LS, Jørgensen NB, Gabe MN, Balk-Møller E, Albrechtsen R, Winther-Sørensen M, Galsgaard KD, Meissner F, Jorsal T, Lund A, Vilsbøll T, Eliasen R, Bojsen-Møller KN, Idorn T, Deacon CF, Knop FK, Rosenkilde MM, Hartmann B, Feldt-Rasmussen B, Mann M, Madsbad S, Holst JJ. Wewer Albrechtsen NJ, et al. Cell Rep. 2017 Nov 7;21(6):1452-1460. doi: 10.1016/j.celrep.2017.10.034. Cell Rep. 2017. PMID: 29117552 Free PMC article.
Evidence of a liver-alpha cell axis in humans: hepatic insulin resistance attenuates relationship between fasting plasma glucagon and glucagonotropic amino acids.
Wewer Albrechtsen NJ, Færch K, Jensen TM, Witte DR, Pedersen J, Mahendran Y, Jonsson AE, Galsgaard KD, Winther-Sørensen M, Torekov SS, Lauritzen T, Pedersen O, Knop FK, Hansen T, Jørgensen ME, Vistisen D, Holst JJ. Wewer Albrechtsen NJ, et al. Diabetologia. 2018 Mar;61(3):671-680. doi: 10.1007/s00125-017-4535-5. Epub 2018 Jan 5. Diabetologia. 2018. PMID: 29305624
The Liver-α-Cell Axis and Type 2 Diabetes.
Wewer Albrechtsen NJ, Pedersen J, Galsgaard KD, Winther-Sørensen M, Suppli MP, Janah L, Gromada J, Vilstrup H, Knop FK, Holst JJ. Wewer Albrechtsen NJ, et al. Endocr Rev. 2019 Oct 1;40(5):1353-1366. doi: 10.1210/er.2018-00251. Endocr Rev. 2019. PMID: 30920583 Review.
Glucagon Receptor Signaling and Glucagon Resistance.
Janah L, Kjeldsen S, Galsgaard KD, Winther-Sørensen M, Stojanovska E, Pedersen J, Knop FK, Holst JJ, Wewer Albrechtsen NJ. Janah L, et al. Int J Mol Sci. 2019 Jul 5;20(13):3314. doi: 10.3390/ijms20133314. Int J Mol Sci. 2019. PMID: 31284506 Free PMC article. Review.
Glucagon receptor signaling is not required for N-carbamoyl glutamate- and l-citrulline-induced ureagenesis in mice.
Galsgaard KD, Pedersen J, Kjeldsen SAS, Winther-Sørensen M, Stojanovska E, Vilstrup H, Ørskov C, Wewer Albrechtsen NJ, Holst JJ. Galsgaard KD, et al. Am J Physiol Gastrointest Liver Physiol. 2020 May 1;318(5):G912-G927. doi: 10.1152/ajpgi.00294.2019. Epub 2020 Mar 16. Am J Physiol Gastrointest Liver Physiol. 2020. PMID: 32174131 Free article.
Neprilysin Inhibition Increases Glucagon Levels in Humans and Mice With Potential Effects on Amino Acid Metabolism.
Kjeldsen SAS, Hansen LH, Esser N, Mongovin S, Winther-Sørensen M, Galsgaard KD, Hunt JE, Kissow H, Ceutz FR, Terzic D, Mark PD, Plomgaard P, Goetze JP, Goossens GH, Blaak EE, Deacon CF, Rosenkilde MM, Zraika S, Holst JJ, Wewer Albrechtsen NJ. Kjeldsen SAS, et al. J Endocr Soc. 2021 May 16;5(9):bvab084. doi: 10.1210/jendso/bvab084. eCollection 2021 Sep 1. J Endocr Soc. 2021. PMID: 34337276 Free PMC article.
23 results