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Drug repurposing screen identifies masitinib as a 3CLpro inhibitor that blocks replication of SARS-CoV-2 in vitro.
Drayman N, Jones KA, Azizi SA, Froggatt HM, Tan K, Maltseva NI, Chen S, Nicolaescu V, Dvorkin S, Furlong K, Kathayat RS, Firpo MR, Mastrodomenico V, Bruce EA, Schmidt MM, Jedrzejczak R, Muñoz-Alía MÁ, Schuster B, Nair V, Botten JW, Brooke CB, Baker SC, Mounce BC, Heaton NS, Dickinson BC, Jaochimiak A, Randall G, Tay S. Drayman N, et al. Among authors: schmidt mm. bioRxiv [Preprint]. 2020 Sep 1:2020.08.31.274639. doi: 10.1101/2020.08.31.274639. bioRxiv. 2020. Update in: Science. 2021 Aug 20;373(6557):931-936. doi: 10.1126/science.abg5827 PMID: 32908976 Free PMC article. Updated. Preprint.
SARS-CoV-2 Disrupts Splicing, Translation, and Protein Trafficking to Suppress Host Defenses.
Banerjee AK, Blanco MR, Bruce EA, Honson DD, Chen LM, Chow A, Bhat P, Ollikainen N, Quinodoz SA, Loney C, Thai J, Miller ZD, Lin AE, Schmidt MM, Stewart DG, Goldfarb D, De Lorenzo G, Rihn SJ, Voorhees RM, Botten JW, Majumdar D, Guttman M. Banerjee AK, et al. Among authors: schmidt mm. Cell. 2020 Nov 25;183(5):1325-1339.e21. doi: 10.1016/j.cell.2020.10.004. Epub 2020 Oct 8. Cell. 2020. PMID: 33080218 Free PMC article.
Masitinib is a broad coronavirus 3CL inhibitor that blocks replication of SARS-CoV-2.
Drayman N, DeMarco JK, Jones KA, Azizi SA, Froggatt HM, Tan K, Maltseva NI, Chen S, Nicolaescu V, Dvorkin S, Furlong K, Kathayat RS, Firpo MR, Mastrodomenico V, Bruce EA, Schmidt MM, Jedrzejczak R, Muñoz-Alía MÁ, Schuster B, Nair V, Han KY, O'Brien A, Tomatsidou A, Meyer B, Vignuzzi M, Missiakas D, Botten JW, Brooke CB, Lee H, Baker SC, Mounce BC, Heaton NS, Severson WE, Palmer KE, Dickinson BC, Joachimiak A, Randall G, Tay S. Drayman N, et al. Among authors: schmidt mm. Science. 2021 Aug 20;373(6557):931-936. doi: 10.1126/science.abg5827. Epub 2021 Jul 20. Science. 2021. PMID: 34285133 Free PMC article.
Quantitative measurement of infectious virus in SARS-CoV-2 Alpha, Delta and Epsilon variants reveals higher infectivity (viral titer:RNA ratio) in clinical samples containing the Delta and Epsilon variants.
Despres HW, Mills MG, Shirley DJ, Schmidt MM, Huang ML, Jerome KR, Greninger AL, Bruce EA. Despres HW, et al. Among authors: schmidt mm. medRxiv [Preprint]. 2021 Sep 20:2021.09.07.21263229. doi: 10.1101/2021.09.07.21263229. medRxiv. 2021. Update in: Proc Natl Acad Sci U S A. 2022 Feb 1;119(5):e2116518119. doi: 10.1073/pnas.2116518119 PMID: 34580674 Free PMC article. Updated. Preprint.
Variant mutation in SARS-CoV-2 nucleocapsid enhances viral infection via altered genomic encapsidation.
Kubinski HC, Despres HW, Johnson BA, Schmidt MM, Jaffrani SA, Mills MG, Lokugamage K, Dumas CM, Shirley DJ, Estes LK, Pekosz A, Crothers JW, Roychoudhury P, Greninger AL, Jerome KR, Di Genova BM, Walker DH, Ballif BA, Ladinsky MS, Bjorkman PJ, Menachery VD, Bruce EA. Kubinski HC, et al. Among authors: schmidt mm. bioRxiv [Preprint]. 2024 Mar 11:2024.03.08.584120. doi: 10.1101/2024.03.08.584120. bioRxiv. 2024. PMID: 38559000 Free PMC article. Preprint.
Surveillance of Vermont wildlife in 2021-2022 reveals no detected SARS-CoV-2 viral RNA.
Despres HW, Mills MG, Schmidt MM, Gov J, Perez Y, Jindrich M, Crawford AML, Kohl WT, Rosenblatt E, Kubinski HC, Simmons BC, Nippes MC, Goldenberg AJ, Murtha KE, Nicoloro S, Harris MJ, Feeley AC, Gelinas TK, Cronin MK, Frederick RS, Thomas M, Johnson ME, Murphy J, Lenzini EB, Carr PA Jr, Berger DH, Mehta SP, Floreani CJ, Koval AC, Young AL, Fish JH, Wallace J, Chaney E, Ushay G, Ross RS, Vostal EM, Thisner MC, Gonet KE, Deane OC, Pelletiere KR, Rockafeller VC, Waterman M, Barry TW, Goering CC, Shipman SD, Shiers AC, Reilly CE, Duff AM, Shirley DJ, Jerome KR, Pérez-Osorio AC, Greninger AL, Fortin N, Mosher BA, Bruce EA. Despres HW, et al. Among authors: schmidt mm. bioRxiv [Preprint]. 2023 Apr 26:2023.04.25.538264. doi: 10.1101/2023.04.25.538264. bioRxiv. 2023. Update in: Sci Rep. 2023 Sep 6;13(1):14683. doi: 10.1038/s41598-023-39232-0 PMID: 37162835 Free PMC article. Updated. Preprint.
125 results