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FGF/FGFR signaling in health and disease.
Xie Y, Su N, Yang J, Tan Q, Huang S, Jin M, Ni Z, Zhang B, Zhang D, Luo F, Chen H, Sun X, Feng JQ, Qi H, Chen L. Xie Y, et al. Among authors: zhang b, zhang d. Signal Transduct Target Ther. 2020 Sep 2;5(1):181. doi: 10.1038/s41392-020-00222-7. Signal Transduct Target Ther. 2020. PMID: 32879300 Free PMC article. Review.
FGFR3 deficient mice have accelerated fracture repair.
Xie Y, Luo F, Xu W, Wang Z, Sun X, Xu M, Huang J, Zhang D, Tan Q, Chen B, Jiang W, Du X, Chen L. Xie Y, et al. Among authors: zhang d. Int J Biol Sci. 2017 Jul 18;13(8):1029-1037. doi: 10.7150/ijbs.19309. eCollection 2017. Int J Biol Sci. 2017. PMID: 28924384 Free PMC article.
Adeno-Associated Virus-Mediated RNAi against Mutant Alleles Attenuates Abnormal Calvarial Phenotypes in an Apert Syndrome Mouse Model.
Luo F, Xie Y, Wang Z, Huang J, Tan Q, Sun X, Li F, Li C, Liu M, Zhang D, Xu M, Su N, Ni Z, Jiang W, Chang J, Chen H, Chen S, Xu X, Deng C, Wang Z, Du X, Chen L. Luo F, et al. Among authors: zhang d. Mol Ther Nucleic Acids. 2018 Dec 7;13:291-302. doi: 10.1016/j.omtn.2018.09.012. Epub 2018 Sep 22. Mol Ther Nucleic Acids. 2018. PMID: 30321816 Free PMC article.
Imbalanced development of anterior and posterior thorax is a causative factor triggering scoliosis.
Chen B, Tan Q, Chen H, Luo F, Xu M, Zhao J, Liu P, Sun X, Su N, Zhang D, Fan W, Liu M, Huang H, Wang Z, Huang J, Zhang R, Li C, Li F, Ni Z, Du X, Jin M, Yang J, Xie Y, Chen L. Chen B, et al. Among authors: zhang r, zhang d. J Orthop Translat. 2019 Jan 7;17:103-111. doi: 10.1016/j.jot.2018.12.001. eCollection 2019 Apr. J Orthop Translat. 2019. PMID: 31194037 Free PMC article.
Rmrp Mutation Disrupts Chondrogenesis and Bone Ossification in Zebrafish Model of Cartilage-Hair Hypoplasia via Enhanced Wnt/β-Catenin Signaling.
Sun X, Zhang R, Liu M, Chen H, Chen L, Luo F, Zhang D, Huang J, Li F, Ni Z, Qi H, Su N, Jin M, Yang J, Tan Q, Du X, Chen B, Huang H, Chen S, Yin L, Xu X, Deng C, Luo L, Xie Y, Chen L. Sun X, et al. Among authors: zhang r, zhang d. J Bone Miner Res. 2019 Nov;34(11):2101-2116. doi: 10.1002/jbmr.3820. Epub 2019 Sep 4. J Bone Miner Res. 2019. PMID: 31237961 Free article.
Dstyk mutation leads to congenital scoliosis-like vertebral malformations in zebrafish via dysregulated mTORC1/TFEB pathway.
Sun X, Zhou Y, Zhang R, Wang Z, Xu M, Zhang D, Huang J, Luo F, Li F, Ni Z, Zhou S, Chen H, Chen S, Chen L, Du X, Chen B, Huang H, Liu P, Yin L, Qiu J, Chen D, Deng C, Xie Y, Luo L, Chen L. Sun X, et al. Among authors: zhang r, zhang d. Nat Commun. 2020 Jan 24;11(1):479. doi: 10.1038/s41467-019-14169-z. Nat Commun. 2020. PMID: 31980602 Free PMC article.
Fgfr3 mutation disrupts chondrogenesis and bone ossification in zebrafish model mimicking CATSHL syndrome partially via enhanced Wnt/β-catenin signaling.
Sun X, Zhang R, Chen H, Du X, Chen S, Huang J, Liu M, Xu M, Luo F, Jin M, Su N, Qi H, Yang J, Tan Q, Zhang D, Ni Z, Liang S, Zhang B, Chen D, Zhang X, Luo L, Chen L, Xie Y. Sun X, et al. Among authors: zhang r, zhang b, zhang d, zhang x. Theranostics. 2020 May 30;10(16):7111-7130. doi: 10.7150/thno.45286. eCollection 2020. Theranostics. 2020. PMID: 32641982 Free PMC article.
Targeting local lymphatics to ameliorate heterotopic ossification via FGFR3-BMPR1a pathway.
Zhang D, Huang J, Sun X, Chen H, Huang S, Yang J, Du X, Tan Q, Luo F, Zhang R, Zhou S, Jiang W, Ni Z, Wang Z, Jin M, Xu M, Li F, Chen L, Liu M, Su N, Luo X, Yin L, Zhu Y, Feng JQ, Chen D, Qi H, Chen L, Xie Y. Zhang D, et al. Among authors: zhang r. Nat Commun. 2021 Jul 19;12(1):4391. doi: 10.1038/s41467-021-24643-2. Nat Commun. 2021. PMID: 34282140 Free PMC article.
Long term usage of dexamethasone accelerating accelerates the initiation of osteoarthritis via enhancing chondrocyte apoptosis and the extracellular matrix calcification and apoptosis of chondrocytes.
Chen L, Ni Z, Huang J, Zhang R, Zhang J, Zhang B, Kuang L, Sun X, Zhang D, Su N, Qi H, Yang J, Jin M, Luo F, Chen H, Zhou S, Du X, Ouyang J, Wang Z, Xie Y, Tan Q, Chen L. Chen L, et al. Among authors: zhang r, zhang b, zhang d, zhang j. Int J Biol Sci. 2021 Oct 3;17(15):4140-4153. doi: 10.7150/ijbs.64152. eCollection 2021. Int J Biol Sci. 2021. PMID: 34803488 Free PMC article.
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