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FGF/FGFR signaling in health and disease.
Xie Y, Su N, Yang J, Tan Q, Huang S, Jin M, Ni Z, Zhang B, Zhang D, Luo F, Chen H, Sun X, Feng JQ, Qi H, Chen L. Xie Y, et al. Among authors: yang j. Signal Transduct Target Ther. 2020 Sep 2;5(1):181. doi: 10.1038/s41392-020-00222-7. Signal Transduct Target Ther. 2020. PMID: 32879300 Free PMC article. Review.
Fgfr3 mutation disrupts chondrogenesis and bone ossification in zebrafish model mimicking CATSHL syndrome partially via enhanced Wnt/β-catenin signaling.
Sun X, Zhang R, Chen H, Du X, Chen S, Huang J, Liu M, Xu M, Luo F, Jin M, Su N, Qi H, Yang J, Tan Q, Zhang D, Ni Z, Liang S, Zhang B, Chen D, Zhang X, Luo L, Chen L, Xie Y. Sun X, et al. Among authors: yang j. Theranostics. 2020 May 30;10(16):7111-7130. doi: 10.7150/thno.45286. eCollection 2020. Theranostics. 2020. PMID: 32641982 Free PMC article.
Imbalanced development of anterior and posterior thorax is a causative factor triggering scoliosis.
Chen B, Tan Q, Chen H, Luo F, Xu M, Zhao J, Liu P, Sun X, Su N, Zhang D, Fan W, Liu M, Huang H, Wang Z, Huang J, Zhang R, Li C, Li F, Ni Z, Du X, Jin M, Yang J, Xie Y, Chen L. Chen B, et al. Among authors: yang j. J Orthop Translat. 2019 Jan 7;17:103-111. doi: 10.1016/j.jot.2018.12.001. eCollection 2019 Apr. J Orthop Translat. 2019. PMID: 31194037 Free PMC article.
Rmrp Mutation Disrupts Chondrogenesis and Bone Ossification in Zebrafish Model of Cartilage-Hair Hypoplasia via Enhanced Wnt/β-Catenin Signaling.
Sun X, Zhang R, Liu M, Chen H, Chen L, Luo F, Zhang D, Huang J, Li F, Ni Z, Qi H, Su N, Jin M, Yang J, Tan Q, Du X, Chen B, Huang H, Chen S, Yin L, Xu X, Deng C, Luo L, Xie Y, Chen L. Sun X, et al. Among authors: yang j. J Bone Miner Res. 2019 Nov;34(11):2101-2116. doi: 10.1002/jbmr.3820. Epub 2019 Sep 4. J Bone Miner Res. 2019. PMID: 31237961 Free article.
FGFR3 deficiency enhances CXCL12-dependent chemotaxis of macrophages via upregulating CXCR7 and aggravates joint destruction in mice.
Kuang L, Wu J, Su N, Qi H, Chen H, Zhou S, Xiong Y, Du X, Tan Q, Yang J, Jin M, Luo F, Ouyang J, Zhang B, Wang Z, Jiang W, Chen L, Chen S, Wang Z, Liu P, Yin L, Guo F, Deng C, Chen D, Liu C, Xie Y, Ni Z, Chen L. Kuang L, et al. Among authors: yang j. Ann Rheum Dis. 2020 Jan;79(1):112-122. doi: 10.1136/annrheumdis-2019-215696. Epub 2019 Oct 29. Ann Rheum Dis. 2020. PMID: 31662319
TGF-β/Alk5 signaling prevents osteoarthritis initiation via regulating the senescence of articular cartilage stem cells.
Tan Q, Wang Q, Kuang L, Zhang J, Peng X, Liang S, Liu M, Chen H, Chen S, Luo X, Qi H, Li C, Luo F, Huang S, Ni Z, Jin M, Su N, Yang J, Yang P, Chen B, Chen L, Du X, Xie Y, Chen L. Tan Q, et al. Among authors: yang p, yang j. J Cell Physiol. 2021 Jul;236(7):5278-5292. doi: 10.1002/jcp.30231. Epub 2021 Jan 16. J Cell Physiol. 2021. PMID: 33452687
Targeting local lymphatics to ameliorate heterotopic ossification via FGFR3-BMPR1a pathway.
Zhang D, Huang J, Sun X, Chen H, Huang S, Yang J, Du X, Tan Q, Luo F, Zhang R, Zhou S, Jiang W, Ni Z, Wang Z, Jin M, Xu M, Li F, Chen L, Liu M, Su N, Luo X, Yin L, Zhu Y, Feng JQ, Chen D, Qi H, Chen L, Xie Y. Zhang D, et al. Among authors: yang j. Nat Commun. 2021 Jul 19;12(1):4391. doi: 10.1038/s41467-021-24643-2. Nat Commun. 2021. PMID: 34282140 Free PMC article.
Long term usage of dexamethasone accelerating accelerates the initiation of osteoarthritis via enhancing chondrocyte apoptosis and the extracellular matrix calcification and apoptosis of chondrocytes.
Chen L, Ni Z, Huang J, Zhang R, Zhang J, Zhang B, Kuang L, Sun X, Zhang D, Su N, Qi H, Yang J, Jin M, Luo F, Chen H, Zhou S, Du X, Ouyang J, Wang Z, Xie Y, Tan Q, Chen L. Chen L, et al. Among authors: yang j. Int J Biol Sci. 2021 Oct 3;17(15):4140-4153. doi: 10.7150/ijbs.64152. eCollection 2021. Int J Biol Sci. 2021. PMID: 34803488 Free PMC article.
Expansion of FGFR3-positive nucleus pulposus cells plays important roles in postnatal nucleus pulposus growth and regeneration.
Xu M, Huang J, Jin M, Jiang W, Luo F, Tan Q, Zhang R, Luo X, Kuang L, Zhang D, Liang S, Qi H, Chen H, Ni Z, Su N, Yang J, Du X, Chen B, Deng C, Xie Y, Chen L. Xu M, et al. Among authors: yang j. Stem Cell Res Ther. 2022 Jun 3;13(1):227. doi: 10.1186/s13287-022-02903-2. Stem Cell Res Ther. 2022. PMID: 35659742 Free PMC article.
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