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Target-Based Identification and Optimization of 5-Indazol-5-yl Pyridones as Toll-like Receptor 7 and 8 Antagonists Using a Biochemical TLR8 Antagonist Competition Assay.
Knoepfel T, Nimsgern P, Jacquier S, Bourrel M, Vangrevelinghe E, Glatthar R, Behnke D, Alper PB, Michellys PY, Deane J, Junt T, Zipfel G, Limonta S, Hawtin S, Andre C, Boulay T, Loetscher P, Faller M, Blank J, Feifel R, Betschart C. Knoepfel T, et al. Among authors: zipfel g. J Med Chem. 2020 Aug 13;63(15):8276-8295. doi: 10.1021/acs.jmedchem.0c00130. Epub 2020 Jul 30. J Med Chem. 2020. PMID: 32786235
Structure-Based Optimization of a Fragment-like TLR8 Binding Screening Hit to an In Vivo Efficacious TLR7/8 Antagonist.
Betschart C, Faller M, Zink F, Hemmig R, Blank J, Vangrevelinghe E, Bourrel M, Glatthar R, Behnke D, Barker K, Heizmann A, Angst D, Nimsgern P, Jacquier S, Junt T, Zipfel G, Ruzzante G, Loetscher P, Limonta S, Hawtin S, Andre CB, Boulay T, Feifel R, Knoepfel T. Betschart C, et al. Among authors: zipfel g. ACS Med Chem Lett. 2022 Mar 10;13(4):658-664. doi: 10.1021/acsmedchemlett.1c00696. eCollection 2022 Apr 14. ACS Med Chem Lett. 2022. PMID: 35450354 Free PMC article.
Nonhematopoietic IRAK1 drives arthritis via neutrophil chemoattractants.
Hoyler T, Bannert B, André C, Beck D, Boulay T, Buffet D, Caesar N, Calzascia T, Dawson J, Kyburz D, Hennze R, Huppertz C, Littlewood-Evans A, Loetscher P, Mertz KD, Niwa S, Robert G, Rush JS, Ruzzante G, Sarret S, Stein T, Touil I, Wieczorek G, Zipfel G, Hawtin S, Junt T. Hoyler T, et al. Among authors: zipfel g. JCI Insight. 2022 Jul 8;7(13):e149825. doi: 10.1172/jci.insight.149825. JCI Insight. 2022. PMID: 35801586 Free PMC article.
Discovery of the TLR7/8 Antagonist MHV370 for Treatment of Systemic Autoimmune Diseases.
Alper P, Betschart C, André C, Boulay T, Cheng D, Deane J, Faller M, Feifel R, Glatthar R, Han D, Hemmig R, Jiang T, Knoepfel T, Maginnis J, Mutnick D, Pei W, Ruzzante G, Syka P, Zhang G, Zhang Y, Zink F, Zipfel G, Hawtin S, Junt T, Michellys PY. Alper P, et al. Among authors: zipfel g. ACS Med Chem Lett. 2023 Jul 31;14(8):1054-1062. doi: 10.1021/acsmedchemlett.3c00136. eCollection 2023 Aug 10. ACS Med Chem Lett. 2023. PMID: 37583811 Free PMC article.
Anti-melanocortin-4 receptor autoantibodies in obesity.
Peter JC, Bekel A, Lecourt AC, Zipfel G, Eftekhari P, Nesslinger M, Breidert M, Muller S, Kessler L, Hofbauer KG. Peter JC, et al. Among authors: zipfel g. J Clin Endocrinol Metab. 2009 Mar;94(3):793-800. doi: 10.1210/jc.2008-1749. Epub 2008 Dec 2. J Clin Endocrinol Metab. 2009. PMID: 19050052 Free article.
Microsurgical Treatment of Intracranial Dural Arteriovenous Fistulas: A Collaborative Investigation From the Multicenter Consortium for Dural Arteriovenous Fistula Outcomes Research.
Raygor KP, Abdelsalam A, Tonetti DA, Raper DMS, Guniganti R, Durnford AJ, Giordan E, Brinjikji W, Chen CJ, Abecassis IJ, Levitt MR, Polifka AJ, Derdeyn CP, Samaniego EA, Kwasnicki A, Alaraj A, Potgieser ARE, Chen S, Tada Y, Kansagra AP, Satomi J, Eatz T, Peterson EC, Starke RM, van Dijk JMC, Amin-Hanjani S, Hayakawa M, Gross BA, Fox WC, Kim L, Sheehan J, Lanzino G, Du R, Lai PMR, Bulters DO, Zipfel GJ, Abla AA; Consortium for Dural Arteriovenous Fistula Outcomes Research. Raygor KP, et al. Among authors: zipfel gj. Neurosurgery. 2024 Oct 8. doi: 10.1227/neu.0000000000003204. Online ahead of print. Neurosurgery. 2024. PMID: 39471093
294 results