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Page 1
Discovery of potent, orally bioavailable in vivo efficacious antagonists of the TLR7/8 pathway.
Alper PB, Deane J, Betschart C, Buffet D, Collignon Zipfel G, Gordon P, Hampton J, Hawtin S, Ibanez M, Jiang T, Junt T, Knoepfel T, Liu B, Maginnis J, McKeever U, Michellys PY, Mutnick D, Nayak B, Niwa S, Richmond W, Rush JS, Syka P, Zhang Y, Zhu X. Alper PB, et al. Among authors: betschart c. Bioorg Med Chem Lett. 2020 Sep 1;30(17):127366. doi: 10.1016/j.bmcl.2020.127366. Epub 2020 Jun 24. Bioorg Med Chem Lett. 2020. PMID: 32738975
Dipeptide nitrile inhibitors of cathepsin K.
Altmann E, Aichholz R, Betschart C, Buhl T, Green J, Lattmann R, Missbach M. Altmann E, et al. Among authors: betschart c. Bioorg Med Chem Lett. 2006 May 1;16(9):2549-54. doi: 10.1016/j.bmcl.2006.01.104. Epub 2006 Feb 9. Bioorg Med Chem Lett. 2006. PMID: 16480867
Novel scaffold for cathepsin K inhibitors.
Teno N, Miyake T, Ehara T, Irie O, Sakaki J, Ohmori O, Gunji H, Matsuura N, Masuya K, Hitomi Y, Nonomura K, Horiuchi M, Gohda K, Iwasaki A, Umemura I, Tada S, Kometani M, Iwasaki G, Cowan-Jacob SW, Missbach M, Lattmann R, Betschart C. Teno N, et al. Among authors: betschart c. Bioorg Med Chem Lett. 2007 Nov 15;17(22):6096-100. doi: 10.1016/j.bmcl.2007.09.047. Epub 2007 Sep 15. Bioorg Med Chem Lett. 2007. PMID: 17911019
New chemotypes for cathepsin K inhibitors.
Teno N, Irie O, Miyake T, Gohda K, Horiuchi M, Tada S, Nonomura K, Kometani M, Iwasaki G, Betschart C. Teno N, et al. Among authors: betschart c. Bioorg Med Chem Lett. 2008 Apr 15;18(8):2599-603. doi: 10.1016/j.bmcl.2008.03.036. Epub 2008 Mar 16. Bioorg Med Chem Lett. 2008. PMID: 18375120
Macrocyclic peptidomimetic beta-secretase (BACE-1) inhibitors with activity in vivo.
Machauer R, Laumen K, Veenstra S, Rondeau JM, Tintelnot-Blomley M, Betschart C, Jaton AL, Desrayaud S, Staufenbiel M, Rabe S, Paganetti P, Neumann U. Machauer R, et al. Among authors: betschart c. Bioorg Med Chem Lett. 2009 Mar 1;19(5):1366-70. doi: 10.1016/j.bmcl.2009.01.055. Epub 2009 Jan 22. Bioorg Med Chem Lett. 2009. PMID: 19195887
Macrocyclic BACE-1 inhibitors acutely reduce Abeta in brain after po application.
Lerchner A, Machauer R, Betschart C, Veenstra S, Rueeger H, McCarthy C, Tintelnot-Blomley M, Jaton AL, Rabe S, Desrayaud S, Enz A, Staufenbiel M, Paganetti P, Rondeau JM, Neumann U. Lerchner A, et al. Among authors: betschart c. Bioorg Med Chem Lett. 2010 Jan 15;20(2):603-7. doi: 10.1016/j.bmcl.2009.11.092. Epub 2009 Nov 22. Bioorg Med Chem Lett. 2010. PMID: 19963375
Discovery of 1H-pyrazolo[3,4-b]pyridines as potent dual orexin receptor antagonists (DORAs).
Behnke D, Cotesta S, Hintermann S, Fendt M, Gee CE, Jacobson LH, Laue G, Meyer A, Wagner T, Badiger S, Chaudhari V, Chebrolu M, Pandit C, Hoyer D, Betschart C. Behnke D, et al. Among authors: betschart c. Bioorg Med Chem Lett. 2015 Dec 1;25(23):5555-60. doi: 10.1016/j.bmcl.2015.10.055. Epub 2015 Oct 19. Bioorg Med Chem Lett. 2015. PMID: 26522950
98 results