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Neuron-based high-content assay and screen for CNS active mitotherapeutics.
Varkuti BH, Kepiro M, Liu Z, Vick K, Avchalumov Y, Pacifico R, MacMullen CM, Kamenecka TM, Puthanveettil SV, Davis RL. Varkuti BH, et al. Sci Adv. 2020 Jan 8;6(2):eaaw8702. doi: 10.1126/sciadv.aaw8702. eCollection 2020 Jan. Sci Adv. 2020. PMID: 31934620 Free PMC article.
Small molecule PGC-1α1 protein stabilizers induce adipocyte Ucp1 expression and uncoupled mitochondrial respiration.
Pettersson-Klein AT, Izadi M, Ferreira DMS, Cervenka I, Correia JC, Martinez-Redondo V, Southern M, Cameron M, Kamenecka T, Agudelo LZ, Porsmyr-Palmertz M, Martens U, Lundgren B, Otrocka M, Jenmalm-Jensen A, Griffin PR, Ruas JL. Pettersson-Klein AT, et al. Among authors: kamenecka t. Mol Metab. 2018 Mar;9:28-42. doi: 10.1016/j.molmet.2018.01.017. Epub 2018 Feb 3. Mol Metab. 2018. PMID: 29428596 Free PMC article.
Small molecule amides as potent ROR-γ selective modulators.
Khan PM, El-Gendy Bel-D, Kumar N, Garcia-Ordonez R, Lin L, Ruiz CH, Cameron MD, Griffin PR, Kamenecka TM. Khan PM, et al. Bioorg Med Chem Lett. 2013 Jan 15;23(2):532-6. doi: 10.1016/j.bmcl.2012.11.025. Epub 2012 Nov 22. Bioorg Med Chem Lett. 2013. PMID: 23232056 Free PMC article.
150 results