Wu C - Search Results

1

Discovery of an Orally Active Small-Molecule Tumor Necrosis Factor-α Inhibitor.

Sun W, Wu Y, Zheng M, Yang Y, Liu Y, Wu C, Zhou Y, Zhang Y, Chen L, Li H. Sun W, et al. Among authors: wu y, wu c. J Med Chem. 2020 Aug 13;63(15):8146-8156. doi: 10.1021/acs.jmedchem.0c00377. Epub 2020 Jul 30. J Med Chem. 2020. PMID: 32667202

2

Synthesis of novel andrographolide beckmann rearrangement derivatives and evaluation of their HK2-related anti-inflammatory activities.

Wang W, Wu Y, Yang K, Wu C, Tang R, Li H, Chen L. Wang W, et al. Among authors: wu y, wu c. Eur J Med Chem. 2019 Jul 1;173:282-293. doi: 10.1016/j.ejmech.2019.04.022. Epub 2019 Apr 16. Eur J Med Chem. 2019. PMID: 31009914

3

Structure based discovery of novel hexokinase 2 inhibitors.

Liu Y, Li M, Zhang Y, Wu C, Yang K, Gao S, Zheng M, Li X, Li H, Chen L. Liu Y, et al. Among authors: wu c. Bioorg Chem. 2020 Mar;96:103609. doi: 10.1016/j.bioorg.2020.103609. Epub 2020 Jan 21. Bioorg Chem. 2020. PMID: 32007722

4

Novel PROTACs for degradation of SHP2 protein.

Zheng M, Liu Y, Wu C, Yang K, Wang Q, Zhou Y, Chen L, Li H. Zheng M, et al. Among authors: wu c. Bioorg Chem. 2021 May;110:104788. doi: 10.1016/j.bioorg.2021.104788. Epub 2021 Mar 1. Bioorg Chem. 2021. PMID: 33706076

5

Rational Design and Synthesis of Novel Dual PROTACs for Simultaneous Degradation of EGFR and PARP.

Zheng M, Huo J, Gu X, Wang Y, Wu C, Zhang Q, Wang W, Liu Y, Liu Y, Zhou X, Chen L, Zhou Y, Li H. Zheng M, et al. Among authors: wu c. J Med Chem. 2021 Jun 10;64(11):7839-7852. doi: 10.1021/acs.jmedchem.1c00649. Epub 2021 May 26. J Med Chem. 2021. PMID: 34038131

6

Physapubescin, a natural withanolide as a kidney-type glutaminase (KGA) inhibitor.

Cheng L, Wu CR, Zhu LH, Li H, Chen LX. Cheng L, et al. Bioorg Med Chem Lett. 2017 Mar 1;27(5):1243-1246. doi: 10.1016/j.bmcl.2017.01.057. Epub 2017 Jan 21. Bioorg Med Chem Lett. 2017. PMID: 28174105

7

New natural inhibitors of hexokinase 2 (HK2): Steroids from Ganoderma sinense.

Bao F, Yang K, Wu C, Gao S, Wang P, Chen L, Li H. Bao F, et al. Among authors: wu c. Fitoterapia. 2018 Mar;125:123-129. doi: 10.1016/j.fitote.2018.01.001. Epub 2018 Jan 4. Fitoterapia. 2018. PMID: 29305912

8

A natural inhibitor of kidney-type glutaminase: a withanolide from Physalis pubescens with potent anti-tumor activity.

Wu C, Zheng M, Gao S, Luan S, Cheng L, Wang L, Li J, Chen L, Li H. Wu C, et al. Oncotarget. 2017 Dec 8;8(69):113516-113530. doi: 10.18632/oncotarget.23058. eCollection 2017 Dec 26. Oncotarget. 2017. PMID: 29371926 Free PMC article.

9

Glutaminase inhibitors: a patent review.

Wu C, Chen L, Jin S, Li H. Wu C, et al. Expert Opin Ther Pat. 2018 Nov;28(11):823-835. doi: 10.1080/13543776.2018.1530759. Epub 2018 Oct 11. Expert Opin Ther Pat. 2018. PMID: 30273516 Review.

10

Analysis of therapeutic targets for SARS-CoV-2 and discovery of potential drugs by computational methods.

Wu C, Liu Y, Yang Y, Zhang P, Zhong W, Wang Y, Wang Q, Xu Y, Li M, Li X, Zheng M, Chen L, Li H. Wu C, et al. Acta Pharm Sin B. 2020 May;10(5):766-788. doi: 10.1016/j.apsb.2020.02.008. Epub 2020 Feb 27. Acta Pharm Sin B. 2020. PMID: 32292689 Free PMC article.

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