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Antibody-mediated inhibition of GDF15-GFRAL activity reverses cancer cachexia in mice.
Suriben R, Chen M, Higbee J, Oeffinger J, Ventura R, Li B, Mondal K, Gao Z, Ayupova D, Taskar P, Li D, Starck SR, Chen HH, McEntee M, Katewa SD, Phung V, Wang M, Kekatpure A, Lakshminarasimhan D, White A, Olland A, Haldankar R, Solloway MJ, Hsu JY, Wang Y, Tang J, Lindhout DA, Allan BB. Suriben R, et al. Among authors: chen hh, chen m. Nat Med. 2020 Aug;26(8):1264-1270. doi: 10.1038/s41591-020-0945-x. Epub 2020 Jul 13. Nat Med. 2020. PMID: 32661391
The Fibronectin-ILT3 Interaction Functions as a Stromal Checkpoint that Suppresses Myeloid Cells.
Paavola KJ, Roda JM, Lin VY, Chen P, O'Hollaren KP, Ventura R, Crawley SC, Li B, Chen HH, Malmersjö S, Sharkov NA, Horner G, Guo W, Kutach AK, Mondal K, Zhang Z, Lichtman JS, Song C, Rivera LB, Liu W, Luo J, Wang Y, Solloway MJ, Allan BB, Kekatpure A, Starck SR, Haldankar R, Fan B, Chu C, Tang J, Molgora M, Colonna M, Kaplan DD, Hsu JY. Paavola KJ, et al. Among authors: chen hh, chen p. Cancer Immunol Res. 2021 Nov;9(11):1283-1297. doi: 10.1158/2326-6066.CIR-21-0240. Epub 2021 Aug 23. Cancer Immunol Res. 2021. PMID: 34426457 Free PMC article.
ILT2 and ILT4 Drive Myeloid Suppression via Both Overlapping and Distinct Mechanisms.
Tian J, Ashique AM, Weeks S, Lan T, Yang H, Chen HH, Song C, Koyano K, Mondal K, Tsai D, Cheung I, Moshrefi M, Kekatpure A, Fan B, Li B, Qurashi S, Rocha L, Aguayo J, Rodgers C, Meza M, Heeke D, Medfisch SM, Chu C, Starck S, Basak NP, Sankaran S, Malhotra M, Crawley S, Tran TT, Duey DY, Ho C, Mikaelian I, Liu W, Rivera LB, Huang J, Paavola KJ, O'Hollaren K, Blum LK, Lin VY, Chen P, Iyer A, He S, Roda JM, Wang Y, Sissons J, Kutach AK, Kaplan DD, Stone GW. Tian J, et al. Among authors: chen hh, chen p. Cancer Immunol Res. 2024 May 2;12(5):592-613. doi: 10.1158/2326-6066.CIR-23-0568. Cancer Immunol Res. 2024. PMID: 38393969
Antitumor Activity of a Novel LAIR1 Antagonist in Combination with Anti-PD1 to Treat Collagen-Rich Solid Tumors.
Rodriguez BL, Huang J, Gibson L, Fradette JJ, Chen HH, Koyano K, Cortez C, Li B, Ho C, Ashique AM, Lin VY, Crawley S, Roda JM, Chen P, Fan B, Kim J, Sissons J, Sitrin J, Kaplan DD, Gibbons DL, Rivera LB. Rodriguez BL, et al. Among authors: chen hh, chen p. Mol Cancer Ther. 2024 Aug 1;23(8):1144-1158. doi: 10.1158/1535-7163.MCT-23-0866. Mol Cancer Ther. 2024. PMID: 38648067
3,001 results