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Proximal tubular-targeted overexpression of the Cyp4a12-20-HETE synthase promotes salt-sensitive hypertension in male mice.
Gilani A, Agostinucci K, Pascale JV, Hossain S, Kandhi S, Pandey V, Garcia V, Nasjletti A, Laniado Schwartzman M. Gilani A, et al. Among authors: garcia v. Am J Physiol Regul Integr Comp Physiol. 2020 Jun 17;319(1):R87-95. doi: 10.1152/ajpregu.00089.2020. Online ahead of print. Am J Physiol Regul Integr Comp Physiol. 2020. PMID: 32633545 Free PMC article.
Angiotensin II receptor blockade or deletion of vascular endothelial ACE does not prevent vascular dysfunction and remodeling in 20-HETE-dependent hypertension.
Garcia V, Joseph G, Shkolnik B, Ding Y, Zhang FF, Gotlinger K, Falck JR, Dakarapu R, Capdevila JH, Bernstein KE, Schwartzman ML. Garcia V, et al. Am J Physiol Regul Integr Comp Physiol. 2015 Jul 1;309(1):R71-8. doi: 10.1152/ajpregu.00039.2015. Epub 2015 Apr 29. Am J Physiol Regul Integr Comp Physiol. 2015. PMID: 25924878 Free PMC article.
High-fat diet-induced obesity and insulin resistance in CYP4a14-/- mice is mediated by 20-HETE.
Gilani A, Pandey V, Garcia V, Agostinucci K, Singh SP, Schragenheim J, Bellner L, Falck JR, Paudyal MP, Capdevila JH, Abraham NG, Laniado Schwartzman M. Gilani A, et al. Among authors: garcia v. Am J Physiol Regul Integr Comp Physiol. 2018 Nov 1;315(5):R934-R944. doi: 10.1152/ajpregu.00125.2018. Epub 2018 Aug 8. Am J Physiol Regul Integr Comp Physiol. 2018. PMID: 30088983 Free PMC article.
19-Hydroxyeicosatetraenoic acid analogs: Antagonism of 20-hydroxyeicosatetraenoic acid-induced vascular sensitization and hypertension.
Dakarapu R, Errabelli R, Manthati VL, Michael Adebesin A, Barma DK, Barma D, Garcia V, Zhang F, Laniado Schwartzman M, Falck JR. Dakarapu R, et al. Among authors: garcia v. Bioorg Med Chem Lett. 2019 Oct 1;29(19):126616. doi: 10.1016/j.bmcl.2019.08.020. Epub 2019 Aug 13. Bioorg Med Chem Lett. 2019. PMID: 31439380 Free PMC article.
1,681 results