Sheng C - Search Results

1

Discovery of Novel PDEδ Degraders for the Treatment of KRAS Mutant Colorectal Cancer.

Cheng J, Li Y, Wang X, Dong G, Sheng C. Cheng J, et al. Among authors: sheng c. J Med Chem. 2020 Jul 23;63(14):7892-7905. doi: 10.1021/acs.jmedchem.0c00929. Epub 2020 Jul 14. J Med Chem. 2020. PMID: 32603594

2

Structure-based de novo design, synthesis, and biological evaluation of non-azole inhibitors specific for lanosterol 14alpha-demethylase of fungi.

Ji H, Zhang W, Zhang M, Kudo M, Aoyama Y, Yoshida Y, Sheng C, Song Y, Yang S, Zhou Y, Lü J, Zhu J. Ji H, et al. Among authors: sheng c. J Med Chem. 2003 Feb 13;46(4):474-85. doi: 10.1021/jm020362c. J Med Chem. 2003. PMID: 12570370

3

Structure-based optimization of azole antifungal agents by CoMFA, CoMSIA, and molecular docking.

Sheng C, Zhang W, Ji H, Zhang M, Song Y, Xu H, Zhu J, Miao Z, Jiang Q, Yao J, Zhou Y, Zhu J, Lü J. Sheng C, et al. J Med Chem. 2006 Apr 20;49(8):2512-25. doi: 10.1021/jm051211n. J Med Chem. 2006. PMID: 16610794

4

3D-QSAR and molecular docking studies on benzothiazole derivatives as Candida albicans N-myristoyltransferase inhibitors.

Sheng C, Zhu J, Zhang W, Zhang M, Ji H, Song Y, Xu H, Yao J, Miao Z, Zhou Y, Zhu J, Lü J. Sheng C, et al. Eur J Med Chem. 2007 Apr;42(4):477-86. doi: 10.1016/j.ejmech.2006.11.001. Epub 2006 Nov 18. Eur J Med Chem. 2007. PMID: 17349719

5

Construction of a three-dimensional pharmacophore for Bcl-2 inhibitors by flexible docking and the multiple copy simultaneous search method.

Zheng CH, Zhou YJ, Zhu J, Ji HT, Chen J, Li YW, Sheng CQ, Lu JG, Jiang JH, Tang H, Song YL. Zheng CH, et al. Bioorg Med Chem. 2007 Oct 1;15(19):6407-17. doi: 10.1016/j.bmc.2007.06.052. Epub 2007 Jul 4. Bioorg Med Chem. 2007. PMID: 17629704

6

Design, synthesis, and in vitro photodynamic activities of benzochloroporphyrin derivatives as tumor photosensitizers.

Yao J, Zhang W, Sheng C, Miao Z, Yang F, Yu J, Zhang L, Song Y, Zhou T, Zhou Y. Yao J, et al. Among authors: sheng c. Bioorg Med Chem Lett. 2008 Jan 1;18(1):293-7. doi: 10.1016/j.bmcl.2007.10.086. Epub 2007 Nov 5. Bioorg Med Chem Lett. 2008. PMID: 18006309

7

New homocamptothecins: synthesis, antitumor activity, and molecular modeling.

Miao Z, Sheng C, Zhang W, Ji H, Zhang J, Shao L, You L, Zhang M, Yao J, Che X. Miao Z, et al. Among authors: sheng c. Bioorg Med Chem. 2008 Feb 1;16(3):1493-510. doi: 10.1016/j.bmc.2007.10.046. Epub 2007 Oct 22. Bioorg Med Chem. 2008. PMID: 18207748

8

Homology modeling and molecular dynamics simulation of N-myristoyltransferase from protozoan parasites: active site characterization and insights into rational inhibitor design.

Sheng C, Ji H, Miao Z, Che X, Yao J, Wang W, Dong G, Guo W, Lü J, Zhang W. Sheng C, et al. J Comput Aided Mol Des. 2009 Jun;23(6):375-89. doi: 10.1007/s10822-009-9267-2. Epub 2009 Apr 16. J Comput Aided Mol Des. 2009. PMID: 19370313

9

Three-dimensional model of lanosterol 14 alpha-demethylase from Cryptococcus neoformans: active-site characterization and insights into azole binding.

Sheng C, Miao Z, Ji H, Yao J, Wang W, Che X, Dong G, Lü J, Guo W, Zhang W. Sheng C, et al. Antimicrob Agents Chemother. 2009 Aug;53(8):3487-95. doi: 10.1128/AAC.01630-08. Epub 2009 May 26. Antimicrob Agents Chemother. 2009. PMID: 19470512 Free PMC article.

10

New azoles with potent antifungal activity: design, synthesis and molecular docking.

Che X, Sheng C, Wang W, Cao Y, Xu Y, Ji H, Dong G, Miao Z, Yao J, Zhang W. Che X, et al. Among authors: sheng c. Eur J Med Chem. 2009 Oct;44(10):4218-26. doi: 10.1016/j.ejmech.2009.05.018. Epub 2009 May 24. Eur J Med Chem. 2009. PMID: 19539408

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