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Classic and new mediators for in vitro modelling of human macrophages.
Luque-Martin R, Mander PK, Leenen PJM, Winther MPJ. Luque-Martin R, et al. Among authors: mander pk. J Leukoc Biol. 2021 Mar;109(3):549-560. doi: 10.1002/JLB.1RU0620-018R. Epub 2020 Jun 27. J Leukoc Biol. 2021. PMID: 32592421 Free PMC article. Review.
IFN-γ Drives Human Monocyte Differentiation into Highly Proinflammatory Macrophages That Resemble a Phenotype Relevant to Psoriasis.
Luque-Martin R, Angell DC, Kalxdorf M, Bernard S, Thompson W, Eberl HC, Ashby C, Freudenberg J, Sharp C, Van den Bossche J, de Jonge WJ, Rioja I, Prinjha RK, Neele AE, de Winther MPJ, Mander PK. Luque-Martin R, et al. Among authors: mander pk. J Immunol. 2021 Jul 15;207(2):555-568. doi: 10.4049/jimmunol.2001310. Epub 2021 Jul 7. J Immunol. 2021. PMID: 34233910
Targeting Histone Deacetylases in Myeloid Cells Inhibits Their Maturation and Inflammatory Function With Limited Effects on Atherosclerosis.
Luque-Martin R, Van den Bossche J, Furze RC, Neele AE, van der Velden S, Gijbels MJJ, van Roomen CPPA, Bernard SG, de Jonge WJ, Rioja I, Prinjha RK, Lewis HD, Mander PK, de Winther MPJ. Luque-Martin R, et al. Among authors: mander pk. Front Pharmacol. 2019 Oct 29;10:1242. doi: 10.3389/fphar.2019.01242. eCollection 2019. Front Pharmacol. 2019. PMID: 31736752 Free PMC article.
Pharmacological validation of targets regulating CD14 during macrophage differentiation.
Jimenez-Duran G, Luque-Martin R, Patel M, Koppe E, Bernard S, Sharp C, Buchan N, Rea C, de Winther MPJ, Turan N, Angell D, Wells CA, Cousins R, Mander PK, Masters SL. Jimenez-Duran G, et al. Among authors: mander pk. EBioMedicine. 2020 Nov;61:103039. doi: 10.1016/j.ebiom.2020.103039. Epub 2020 Oct 7. EBioMedicine. 2020. PMID: 33038762 Free PMC article.
Carboxylesterase-1 Assisted Targeting of HDAC Inhibitors to Mononuclear Myeloid Cells in Inflammatory Bowel Disease.
Elfiky AMI, Ghiboub M, Li Yim AYF, Hageman IL, Verhoeff J, de Krijger M, van Hamersveld PHP, Welting O, Admiraal I, Rahman S, Garcia-Vallejo JJ, Wildenberg ME, Tomlinson L, Gregory R, Rioja I, Prinjha RK, Furze RC, Lewis HD, Mander PK, Heinsbroek SEM, Bell MJ, de Jonge WJ. Elfiky AMI, et al. Among authors: mander pk. J Crohns Colitis. 2022 May 10;16(4):668-681. doi: 10.1093/ecco-jcc/jjab176. J Crohns Colitis. 2022. PMID: 34633041 Free PMC article.
A BET Protein Inhibitor Targeting Mononuclear Myeloid Cells Affects Specific Inflammatory Mediators and Pathways in Crohn's Disease.
Elfiky AMI, Hageman IL, Becker MAJ, Verhoeff J, Li Yim AYF, Joustra VW, Mulders L, Fung I, Rioja I, Prinjha RK, Smithers NN, Furze RC, Mander PK, Bell MJ, Buskens CJ, D'Haens GR, Wildenberg ME, de Jonge WJ. Elfiky AMI, et al. Among authors: mander pk. Cells. 2022 Sep 12;11(18):2846. doi: 10.3390/cells11182846. Cells. 2022. PMID: 36139421 Free PMC article.
Histone H3K27me3 demethylases regulate human Th17 cell development and effector functions by impacting on metabolism.
Cribbs AP, Terlecki-Zaniewicz S, Philpott M, Baardman J, Ahern D, Lindow M, Obad S, Oerum H, Sampey B, Mander PK, Penn H, Wordsworth P, Bowness P, de Winther M, Prinjha RK, Feldmann M, Oppermann U. Cribbs AP, et al. Among authors: mander pk. Proc Natl Acad Sci U S A. 2020 Mar 17;117(11):6056-6066. doi: 10.1073/pnas.1919893117. Epub 2020 Mar 2. Proc Natl Acad Sci U S A. 2020. PMID: 32123118 Free PMC article.
BET Inhibition Improves NASH and Liver Fibrosis.
Middleton SA, Rajpal N, Cutler L, Mander P, Rioja I, Prinjha RK, Rajpal D, Agarwal P, Kumar V. Middleton SA, et al. Sci Rep. 2018 Nov 22;8(1):17257. doi: 10.1038/s41598-018-35653-4. Sci Rep. 2018. PMID: 30467325 Free PMC article.
24 results