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The presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid beta protein ending at the 42nd (or 43rd) residue.
Tomita T, Maruyama K, Saido TC, Kume H, Shinozaki K, Tokuhiro S, Capell A, Walter J, Grünberg J, Haass C, Iwatsubo T, Obata K. Tomita T, et al. Among authors: haass c. Proc Natl Acad Sci U S A. 1997 Mar 4;94(5):2025-30. doi: 10.1073/pnas.94.5.2025. Proc Natl Acad Sci U S A. 1997. PMID: 9050898 Free PMC article.
Mutant presenilin 2 transgenic mouse: effect on an age-dependent increase of amyloid beta-protein 42 in the brain.
Oyama F, Sawamura N, Kobayashi K, Morishima-Kawashima M, Kuramochi T, Ito M, Tomita T, Maruyama K, Saido TC, Iwatsubo T, Capell A, Walter J, Grünberg J, Ueyama Y, Haass C, Ihara Y. Oyama F, et al. Among authors: haass c. J Neurochem. 1998 Jul;71(1):313-22. doi: 10.1046/j.1471-4159.1998.71010313.x. J Neurochem. 1998. PMID: 9648880 Free article.
Maturation and pro-peptide cleavage of beta-secretase.
Capell A, Steiner H, Willem M, Kaiser H, Meyer C, Walter J, Lammich S, Multhaup G, Haass C. Capell A, et al. Among authors: haass c. J Biol Chem. 2000 Oct 6;275(40):30849-54. doi: 10.1074/jbc.M003202200. J Biol Chem. 2000. PMID: 10801872 Free article.
A non-amyloidogenic function of BACE-2 in the secretory pathway.
Fluhrer R, Capell A, Westmeyer G, Willem M, Hartung B, Condron MM, Teplow DB, Haass C, Walter J. Fluhrer R, et al. Among authors: haass c. J Neurochem. 2002 Jun;81(5):1011-20. doi: 10.1046/j.1471-4159.2002.00908.x. J Neurochem. 2002. PMID: 12065613 Free article.
473 results