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Exposure of a cryptic Hsp70 binding site determines the cytotoxicity of the ALS-associated SOD1-mutant A4V.
Claes F, Rudyak S, Laird AS, Louros N, Beerten J, Debulpaep M, Michiels E, van der Kant R, Van Durme J, De Baets G, Houben B, Ramakers M, Yuan K, Gwee SSL, Hernandez S, Broersen K, Oliveberg M, Moahamed B, Kirstein J, Robberecht W, Rousseau F, Schymkowitz J. Claes F, et al. Among authors: louros n. Protein Eng Des Sel. 2019 Dec 31;32(10):443-457. doi: 10.1093/protein/gzaa008. Protein Eng Des Sel. 2019. PMID: 32399571
Aggregating sequences that occur in many proteins constitute weak spots of bacterial proteostasis.
Khodaparast L, Khodaparast L, Gallardo R, Louros NN, Michiels E, Ramakrishnan R, Ramakers M, Claes F, Young L, Shahrooei M, Wilkinson H, Desager M, Mengistu Tadesse W, Nilsson KPR, Hammarström P, Aertsen A, Carpentier S, Van Eldere J, Rousseau F, Schymkowitz J. Khodaparast L, et al. Among authors: louros nn. Nat Commun. 2018 Feb 28;9(1):866. doi: 10.1038/s41467-018-03131-0. Nat Commun. 2018. PMID: 29491361 Free PMC article.
Entropic Bristles Tune the Seeding Efficiency of Prion-Nucleating Fragments.
Michiels E, Liu S, Gallardo R, Louros N, Mathelié-Guinlet M, Dufrêne Y, Schymkowitz J, Vorberg I, Rousseau F. Michiels E, et al. Among authors: louros n. Cell Rep. 2020 Feb 25;30(8):2834-2845.e3. doi: 10.1016/j.celrep.2020.01.098. Cell Rep. 2020. PMID: 32101755 Free PMC article.
Reverse engineering synthetic antiviral amyloids.
Michiels E, Roose K, Gallardo R, Khodaparast L, Khodaparast L, van der Kant R, Siemons M, Houben B, Ramakers M, Wilkinson H, Guerreiro P, Louros N, Kaptein SJF, Ibañez LI, Smet A, Baatsen P, Liu S, Vorberg I, Bormans G, Neyts J, Saelens X, Rousseau F, Schymkowitz J. Michiels E, et al. Among authors: louros n. Nat Commun. 2020 Jun 5;11(1):2832. doi: 10.1038/s41467-020-16721-8. Nat Commun. 2020. PMID: 32504029 Free PMC article.
The structural basis for an on-off switch controlling Gβγ-mediated inhibition of TRPM3 channels.
Behrendt M, Gruss F, Enzeroth R, Dembla S, Zhao S, Crassous PA, Mohr F, Nys M, Louros N, Gallardo R, Zorzini V, Wagner D, Economou A, Rousseau F, Schymkowitz J, Philipp SE, Rohacs T, Ulens C, Oberwinkler J. Behrendt M, et al. Among authors: louros n. Proc Natl Acad Sci U S A. 2020 Nov 17;117(46):29090-29100. doi: 10.1073/pnas.2001177117. Epub 2020 Oct 29. Proc Natl Acad Sci U S A. 2020. PMID: 33122432 Free PMC article.
130 results