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Combined treatment with epoxyeicosatrienoic acid analog and 20-hydroxyeicosatetraenoic acid antagonist provides substantial hypotensive effect in spontaneously hypertensive rats.
Gawrys O, Husková Z, Baranowska I, Walkowska A, Sadowski J, Kikerlová S, Vaňourková Z, Honetschlägerová Z, Škaroupková P, Červenka L, Falck JR, Imig JD, Kompanowska-Jezierska E. Gawrys O, et al. Among authors: sadowski j. J Hypertens. 2020 Sep;38(9):1802-1810. doi: 10.1097/HJH.0000000000002462. J Hypertens. 2020. PMID: 32384390
Intrarenal cytochrome P-450 metabolites of arachidonic acid in the regulation of the nonclipped kidney function in two-kidney, one-clip Goldblatt hypertensive rats.
Walkowska A, Skaroupková P, Husková Z, Vanourková Z, Chábová VC, Tesar V, Kramer HJ, Falck JR, Imig JD, Kompanowska-Jezierska E, Sadowski J, Cervenka L. Walkowska A, et al. Among authors: sadowski j. J Hypertens. 2010 Mar;28(3):582-93. doi: 10.1097/HJH.0b013e328334dfd4. J Hypertens. 2010. PMID: 19940786 Free PMC article.
Combined inhibition of 20-hydroxyeicosatetraenoic acid formation and of epoxyeicosatrienoic acids degradation attenuates hypertension and hypertension-induced end-organ damage in Ren-2 transgenic rats.
Certíková Chábová V, Walkowska A, Kompanowska-Jezierska E, Sadowski J, Kujal P, Vernerová Z, Vanourková Z, Kopkan L, Kramer HJ, Falck JR, Imig JD, Hammock BD, Vanecková I, Cervenka L. Certíková Chábová V, et al. Among authors: sadowski j. Clin Sci (Lond). 2010 Feb 23;118(10):617-32. doi: 10.1042/CS20090459. Clin Sci (Lond). 2010. PMID: 20050826 Free PMC article.
Inhibition of soluble epoxide hydrolase is renoprotective in 5/6 nephrectomized Ren-2 transgenic hypertensive rats.
Kujal P, Čertíková Chábová V, Škaroupková P, Husková Z, Vernerová Z, Kramer HJ, Walkowska A, Kompanowska-Jezierska E, Sadowski J, Kitada K, Nishiyama A, Hwang SH, Hammock BD, Imig JD, Červenka L. Kujal P, et al. Among authors: sadowski j. Clin Exp Pharmacol Physiol. 2014 Mar;41(3):227-37. doi: 10.1111/1440-1681.12204. Clin Exp Pharmacol Physiol. 2014. PMID: 24471737 Free PMC article.
Orally active epoxyeicosatrienoic acid analog does not exhibit antihypertensive and reno- or cardioprotective actions in two-kidney, one-clip Goldblatt hypertensive rats.
Alánová P, Husková Z, Kopkan L, Sporková A, Jíchová Š, Neckář J, Imig JD, Klevstig M, Kolář F, Rami Reddy N, Falck JR, Sadowski J, Nishiyama A, Kramer HJ, Melenovský V, Červenková L, Kujal P, Vernerová Z, Červenka L. Alánová P, et al. Among authors: sadowski j. Vascul Pharmacol. 2015 Oct;73:45-56. doi: 10.1016/j.vph.2015.08.013. Epub 2015 Aug 22. Vascul Pharmacol. 2015. PMID: 26304700
Epoxyeicosatrienoic acid analog attenuates the development of malignant hypertension, but does not reverse it once established: a study in Cyp1a1-Ren-2 transgenic rats.
Jíchová Š, Kopkan L, Husková Z, Doleželová Š, Neckář J, Kujal P, Vernerová Z, Kramer HJ, Sadowski J, Kompanowska-Jezierska E, Reddy RN, Falck JR, Imig JD, Červenka L. Jíchová Š, et al. Among authors: sadowski j. J Hypertens. 2016 Oct;34(10):2008-25. doi: 10.1097/HJH.0000000000001029. J Hypertens. 2016. PMID: 27428043 Free PMC article.
Progression of hypertension and kidney disease in aging fawn-hooded rats is mediated by enhanced influence of renin-angiotensin system and suppression of nitric oxide system and epoxyeicosanoids.
Doleželová Š, Jíchová Š, Husková Z, Vojtíšková A, Kujal P, Hošková L, Kautzner J, Sadowski J, Červenka L, Kopkan L. Doleželová Š, et al. Among authors: sadowski j. Clin Exp Hypertens. 2016;38(7):644-651. doi: 10.1080/10641963.2016.1182182. Epub 2016 Sep 26. Clin Exp Hypertens. 2016. PMID: 27669111
Renin-angiotensin system blockade alone or combined with ETA receptor blockade: effects on the course of chronic kidney disease in 5/6 nephrectomized Ren-2 transgenic hypertensive rats.
Sedláková L, Čertíková Chábová V, Doleželová Š, Škaroupková P, Kopkan L, Husková Z, Červenková L, Kikerlová S, Vaněčková I, Sadowski J, Kompanowska-Jezierska E, Kujal P, Kramer HJ, Červenka L. Sedláková L, et al. Among authors: sadowski j. Clin Exp Hypertens. 2017;39(2):183-195. doi: 10.1080/10641963.2016.1235184. Epub 2017 Mar 1. Clin Exp Hypertens. 2017. PMID: 28287881
Fenofibrate Attenuates Hypertension in Goldblatt Hypertensive Rats: Role of 20-Hydroxyeicosatetraenoic Acid in the Nonclipped Kidney.
Sporková A, Čertíková Chábová V, Doleželová Š, Jíchová Š, Kopkan L, Vaňourková Z, Kompanowska-Jezierska E, Sadowski J, Maxová H, Červenka L. Sporková A, et al. Among authors: sadowski j. Am J Med Sci. 2017 Jun;353(6):568-579. doi: 10.1016/j.amjms.2017.04.009. Epub 2017 Apr 12. Am J Med Sci. 2017. PMID: 28641720
802 results