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Combined treatment with epoxyeicosatrienoic acid analog and 20-hydroxyeicosatetraenoic acid antagonist provides substantial hypotensive effect in spontaneously hypertensive rats.
Gawrys O, Husková Z, Baranowska I, Walkowska A, Sadowski J, Kikerlová S, Vaňourková Z, Honetschlägerová Z, Škaroupková P, Červenka L, Falck JR, Imig JD, Kompanowska-Jezierska E. Gawrys O, et al. Among authors: imig jd. J Hypertens. 2020 Sep;38(9):1802-1810. doi: 10.1097/HJH.0000000000002462. J Hypertens. 2020. PMID: 32384390
Addition of Endothelin A-Receptor Blockade Spoils the Beneficial Effect of Combined Renin-Angiotensin and Soluble Epoxide Hydrolase Inhibition: Studies on the Course of Chronic Kidney Disease in 5/6 Nephrectomized Ren-2 Transgenic Hypertensive Rats.
Čertíková Chábová V, Kujal P, Vaňourková Z, Škaroupková P, Sadowski J, Kompanowska-Jezierska E, Tesař V, Hammock B, Imig J, Maxová H, Červenka L, Vaněčková I. Čertíková Chábová V, et al. Kidney Blood Press Res. 2019;44(6):1493-1505. doi: 10.1159/000504137. Epub 2019 Nov 26. Kidney Blood Press Res. 2019. PMID: 31770762 Free PMC article.
The roles of intrarenal 20-hydroxyeicosatetraenoic and epoxyeicosatrienoic acids in the regulation of renal function in hypertensive Ren-2 transgenic rats.
Certíková Chábová V, Kramer HJ, Vanecková I, Thumová M, Skaroupková P, Tesar V, Falck JR, Imig JD, Cervenka L. Certíková Chábová V, et al. Among authors: imig jd. Kidney Blood Press Res. 2007;30(5):335-46. doi: 10.1159/000107710. Epub 2007 Aug 30. Kidney Blood Press Res. 2007. PMID: 17785988
Intrarenal cytochrome P-450 metabolites of arachidonic acid in the regulation of the nonclipped kidney function in two-kidney, one-clip Goldblatt hypertensive rats.
Walkowska A, Skaroupková P, Husková Z, Vanourková Z, Chábová VC, Tesar V, Kramer HJ, Falck JR, Imig JD, Kompanowska-Jezierska E, Sadowski J, Cervenka L. Walkowska A, et al. Among authors: imig jd. J Hypertens. 2010 Mar;28(3):582-93. doi: 10.1097/HJH.0b013e328334dfd4. J Hypertens. 2010. PMID: 19940786 Free PMC article.
Combined inhibition of 20-hydroxyeicosatetraenoic acid formation and of epoxyeicosatrienoic acids degradation attenuates hypertension and hypertension-induced end-organ damage in Ren-2 transgenic rats.
Certíková Chábová V, Walkowska A, Kompanowska-Jezierska E, Sadowski J, Kujal P, Vernerová Z, Vanourková Z, Kopkan L, Kramer HJ, Falck JR, Imig JD, Hammock BD, Vanecková I, Cervenka L. Certíková Chábová V, et al. Among authors: imig jd. Clin Sci (Lond). 2010 Feb 23;118(10):617-32. doi: 10.1042/CS20090459. Clin Sci (Lond). 2010. PMID: 20050826 Free PMC article.
Inhibition of soluble epoxide hydrolase improves the impaired pressure-natriuresis relationship and attenuates the development of hypertension and hypertension-associated end-organ damage in Cyp1a1-Ren-2 transgenic rats.
Honetschlägerová Z, Sporková A, Kopkan L, Husková Z, Hwang SH, Hammock BD, Imig JD, Kramer HJ, Kujal P, Vernerová Z, Chábová VC, Tesař V, Cervenka L. Honetschlägerová Z, et al. Among authors: imig jd. J Hypertens. 2011 Aug;29(8):1590-601. doi: 10.1097/HJH.0b013e328349062f. J Hypertens. 2011. PMID: 21720266 Free PMC article.
Antihypertensive and renoprotective actions of soluble epoxide hydrolase inhibition in ANG II-dependent malignant hypertension are abolished by pretreatment with L-NAME.
Honetschlägerová Z, Kitada K, Husková Z, Sporková A, Kopkan L, Bürgelová M, Varcabová Š, Nishiyama A, Hwang SH, Hammock BD, Imig JD, Kramer HJ, Kujal P, Vernerová Z, Červenka L. Honetschlägerová Z, et al. Among authors: imig jd. J Hypertens. 2013 Feb;31(2):321-32. doi: 10.1097/HJH.0b013e32835b50aa. J Hypertens. 2013. PMID: 23307303 Free PMC article.
Inhibition of soluble epoxide hydrolase is renoprotective in 5/6 nephrectomized Ren-2 transgenic hypertensive rats.
Kujal P, Čertíková Chábová V, Škaroupková P, Husková Z, Vernerová Z, Kramer HJ, Walkowska A, Kompanowska-Jezierska E, Sadowski J, Kitada K, Nishiyama A, Hwang SH, Hammock BD, Imig JD, Červenka L. Kujal P, et al. Among authors: imig jd. Clin Exp Pharmacol Physiol. 2014 Mar;41(3):227-37. doi: 10.1111/1440-1681.12204. Clin Exp Pharmacol Physiol. 2014. PMID: 24471737 Free PMC article.
Orally active epoxyeicosatrienoic acid analog does not exhibit antihypertensive and reno- or cardioprotective actions in two-kidney, one-clip Goldblatt hypertensive rats.
Alánová P, Husková Z, Kopkan L, Sporková A, Jíchová Š, Neckář J, Imig JD, Klevstig M, Kolář F, Rami Reddy N, Falck JR, Sadowski J, Nishiyama A, Kramer HJ, Melenovský V, Červenková L, Kujal P, Vernerová Z, Červenka L. Alánová P, et al. Among authors: imig jd. Vascul Pharmacol. 2015 Oct;73:45-56. doi: 10.1016/j.vph.2015.08.013. Epub 2015 Aug 22. Vascul Pharmacol. 2015. PMID: 26304700
250 results