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Ligand-dependent downregulation of MR1 cell surface expression.
Salio M, Awad W, Veerapen N, Gonzalez-Lopez C, Kulicke C, Waithe D, Martens AWJ, Lewinsohn DM, Hobrath JV, Cox LR, Rossjohn J, Besra GS, Cerundolo V. Salio M, et al. Among authors: awad w. Proc Natl Acad Sci U S A. 2020 May 12;117(19):10465-10475. doi: 10.1073/pnas.2003136117. Epub 2020 Apr 27. Proc Natl Acad Sci U S A. 2020. PMID: 32341160 Free PMC article.
MR1-restricted mucosal-associated invariant T (MAIT) cells respond to mycobacterial vaccination and infection in nonhuman primates.
Greene JM, Dash P, Roy S, McMurtrey C, Awad W, Reed JS, Hammond KB, Abdulhaqq S, Wu HL, Burwitz BJ, Roth BF, Morrow DW, Ford JC, Xu G, Bae JY, Crank H, Legasse AW, Dang TH, Greenaway HY, Kurniawan M, Gold MC, Harriff MJ, Lewinsohn DA, Park BS, Axthelm MK, Stanton JJ, Hansen SG, Picker LJ, Venturi V, Hildebrand W, Thomas PG, Lewinsohn DM, Adams EJ, Sacha JB. Greene JM, et al. Among authors: awad w. Mucosal Immunol. 2017 May;10(3):802-813. doi: 10.1038/mi.2016.91. Epub 2016 Oct 19. Mucosal Immunol. 2017. PMID: 27759023 Free PMC article.
A class of γδ T cell receptors recognize the underside of the antigen-presenting molecule MR1.
Le Nours J, Gherardin NA, Ramarathinam SH, Awad W, Wiede F, Gully BS, Khandokar Y, Praveena T, Wubben JM, Sandow JJ, Webb AI, von Borstel A, Rice MT, Redmond SJ, Seneviratna R, Sandoval-Romero ML, Li S, Souter MNT, Eckle SBG, Corbett AJ, Reid HH, Liu L, Fairlie DP, Giles EM, Westall GP, Tothill RW, Davey MS, Berry R, Tiganis T, McCluskey J, Pellicci DG, Purcell AW, Uldrich AP, Godfrey DI, Rossjohn J. Le Nours J, et al. Among authors: awad w. Science. 2019 Dec 20;366(6472):1522-1527. doi: 10.1126/science.aav3900. Science. 2019. PMID: 31857486
Absence of mucosal-associated invariant T cells in a person with a homozygous point mutation in MR1.
Howson LJ, Awad W, von Borstel A, Lim HJ, McWilliam HEG, Sandoval-Romero ML, Majumdar S, Hamzeh AR, Andrews TD, McDermott DH, Murphy PM, Le Nours J, Mak JYW, Liu L, Fairlie DP, McCluskey J, Villadangos JA, Cook MC, Turner SJ, Davey MS, Ojaimi S, Rossjohn J. Howson LJ, et al. Among authors: awad w. Sci Immunol. 2020 Jul 24;5(49):eabc9492. doi: 10.1126/sciimmunol.abc9492. Sci Immunol. 2020. PMID: 32709702 Free PMC article.
Endoplasmic reticulum chaperones stabilize ligand-receptive MR1 molecules for efficient presentation of metabolite antigens.
McWilliam HEG, Mak JYW, Awad W, Zorkau M, Cruz-Gomez S, Lim HJ, Yan Y, Wormald S, Dagley LF, Eckle SBG, Corbett AJ, Liu H, Li S, Reddiex SJJ, Mintern JD, Liu L, McCluskey J, Rossjohn J, Fairlie DP, Villadangos JA. McWilliam HEG, et al. Among authors: awad w. Proc Natl Acad Sci U S A. 2020 Oct 6;117(40):24974-24985. doi: 10.1073/pnas.2011260117. Epub 2020 Sep 21. Proc Natl Acad Sci U S A. 2020. PMID: 32958637 Free PMC article.
Recognition of the antigen-presenting molecule MR1 by a Vδ3+ γδ T cell receptor.
Rice MT, von Borstel A, Chevour P, Awad W, Howson LJ, Littler DR, Gherardin NA, Le Nours J, Giles EM, Berry R, Godfrey DI, Davey MS, Rossjohn J, Gully BS. Rice MT, et al. Among authors: awad w. Proc Natl Acad Sci U S A. 2021 Dec 7;118(49):e2110288118. doi: 10.1073/pnas.2110288118. Proc Natl Acad Sci U S A. 2021. PMID: 34845016 Free PMC article.
235 results