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Regulatory myeloid cells paralyze T cells through cell-cell transfer of the metabolite methylglyoxal.
Baumann T, Dunkel A, Schmid C, Schmitt S, Hiltensperger M, Lohr K, Laketa V, Donakonda S, Ahting U, Lorenz-Depiereux B, Heil JE, Schredelseker J, Simeoni L, Fecher C, Körber N, Bauer T, Hüser N, Hartmann D, Laschinger M, Eyerich K, Eyerich S, Anton M, Streeter M, Wang T, Schraven B, Spiegel D, Assaad F, Misgeld T, Zischka H, Murray PJ, Heine A, Heikenwälder M, Korn T, Dawid C, Hofmann T, Knolle PA, Höchst B. Baumann T, et al. Among authors: korn t. Nat Immunol. 2020 May;21(5):555-566. doi: 10.1038/s41590-020-0666-9. Epub 2020 Apr 23. Nat Immunol. 2020. PMID: 32327756
CCL17-expressing dendritic cells drive atherosclerosis by restraining regulatory T cell homeostasis in mice.
Weber C, Meiler S, Döring Y, Koch M, Drechsler M, Megens RT, Rowinska Z, Bidzhekov K, Fecher C, Ribechini E, van Zandvoort MA, Binder CJ, Jelinek I, Hristov M, Boon L, Jung S, Korn T, Lutz MB, Förster I, Zenke M, Hieronymus T, Junt T, Zernecke A. Weber C, et al. Among authors: korn t. J Clin Invest. 2011 Jul;121(7):2898-910. doi: 10.1172/JCI44925. J Clin Invest. 2011. PMID: 21633167 Free PMC article.
Uncoupling Malt1 threshold function from paracaspase activity results in destructive autoimmune inflammation.
Gewies A, Gorka O, Bergmann H, Pechloff K, Petermann F, Jeltsch KM, Rudelius M, Kriegsmann M, Weichert W, Horsch M, Beckers J, Wurst W, Heikenwalder M, Korn T, Heissmeyer V, Ruland J. Gewies A, et al. Among authors: korn t. Cell Rep. 2014 Nov 20;9(4):1292-305. doi: 10.1016/j.celrep.2014.10.044. Epub 2014 Nov 13. Cell Rep. 2014. PMID: 25456129 Free article.
Trans-presentation of IL-6 by dendritic cells is required for the priming of pathogenic TH17 cells.
Heink S, Yogev N, Garbers C, Herwerth M, Aly L, Gasperi C, Husterer V, Croxford AL, Möller-Hackbarth K, Bartsch HS, Sotlar K, Krebs S, Regen T, Blum H, Hemmer B, Misgeld T, Wunderlich TF, Hidalgo J, Oukka M, Rose-John S, Schmidt-Supprian M, Waisman A, Korn T. Heink S, et al. Among authors: korn t. Nat Immunol. 2017 Jan;18(1):74-85. doi: 10.1038/ni.3632. Epub 2016 Nov 28. Nat Immunol. 2017. PMID: 27893700 Free PMC article.
T cell responses in the central nervous system.
Korn T, Kallies A. Korn T, et al. Nat Rev Immunol. 2017 Mar;17(3):179-194. doi: 10.1038/nri.2016.144. Epub 2017 Jan 31. Nat Rev Immunol. 2017. PMID: 28138136 Review.
256 results