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PNOCARC Neurons Promote Hyperphagia and Obesity upon High-Fat-Diet Feeding.
Jais A, Paeger L, Sotelo-Hitschfeld T, Bremser S, Prinzensteiner M, Klemm P, Mykytiuk V, Widdershooven PJM, Vesting AJ, Grzelka K, Minère M, Cremer AL, Xu J, Korotkova T, Lowell BB, Zeilhofer HU, Backes H, Fenselau H, Wunderlich FT, Kloppenburg P, Brüning JC. Jais A, et al. Among authors: klemm p. Neuron. 2020 Jun 17;106(6):1009-1025.e10. doi: 10.1016/j.neuron.2020.03.022. Epub 2020 Apr 16. Neuron. 2020. PMID: 32302532 Free PMC article.
MCH Neurons Regulate Permeability of the Median Eminence Barrier.
Jiang H, Gallet S, Klemm P, Scholl P, Folz-Donahue K, Altmüller J, Alber J, Heilinger C, Kukat C, Loyens A, Müller-Fielitz H, Sundaram S, Schwaninger M, Prevot V, Brüning JC. Jiang H, et al. Among authors: klemm p. Neuron. 2020 Jul 22;107(2):306-319.e9. doi: 10.1016/j.neuron.2020.04.020. Epub 2020 May 13. Neuron. 2020. PMID: 32407670 Free PMC article.
Functionally distinct POMC-expressing neuron subpopulations in hypothalamus revealed by intersectional targeting.
Biglari N, Gaziano I, Schumacher J, Radermacher J, Paeger L, Klemm P, Chen W, Corneliussen S, Wunderlich CM, Sue M, Vollmar S, Klöckener T, Sotelo-Hitschfeld T, Abbasloo A, Edenhofer F, Reimann F, Gribble FM, Fenselau H, Kloppenburg P, Wunderlich FT, Brüning JC. Biglari N, et al. Among authors: klemm p. Nat Neurosci. 2021 Jul;24(7):913-929. doi: 10.1038/s41593-021-00854-0. Epub 2021 May 17. Nat Neurosci. 2021. PMID: 34002087 Free PMC article.
Insulin signalling in tanycytes gates hypothalamic insulin uptake and regulation of AgRP neuron activity.
Porniece Kumar M, Cremer AL, Klemm P, Steuernagel L, Sundaram S, Jais A, Hausen AC, Tao J, Secher A, Pedersen TÅ, Schwaninger M, Wunderlich FT, Lowell BB, Backes H, Brüning JC. Porniece Kumar M, et al. Among authors: klemm p. Nat Metab. 2021 Dec;3(12):1662-1679. doi: 10.1038/s42255-021-00499-0. Epub 2021 Dec 20. Nat Metab. 2021. PMID: 34931084 Free PMC article.
HypoMap-a unified single-cell gene expression atlas of the murine hypothalamus.
Steuernagel L, Lam BYH, Klemm P, Dowsett GKC, Bauder CA, Tadross JA, Hitschfeld TS, Del Rio Martin A, Chen W, de Solis AJ, Fenselau H, Davidsen P, Cimino I, Kohnke SN, Rimmington D, Coll AP, Beyer A, Yeo GSH, Brüning JC. Steuernagel L, et al. Among authors: klemm p. Nat Metab. 2022 Oct;4(10):1402-1419. doi: 10.1038/s42255-022-00657-y. Epub 2022 Oct 20. Nat Metab. 2022. PMID: 36266547 Free PMC article.
NIK/MAP3K14 in hepatocytes orchestrates NASH to hepatocellular carcinoma progression via JAK2/STAT5 inhibition.
Vesting AJ, Jais A, Klemm P, Steuernagel L, Wienand P, Fog-Tonnesen M, Hvid H, Schumacher AL, Kukat C, Nolte H, Georgomanolis T, Altmüller J, Pasparakis M, Schmidt A, Krüger M, Supprian MS, Waisman A, Straub BK, Raschzok N, Bernier M, Birkenfeld AL, Hövelmeyer N, Brüning JC, Wunderlich FT. Vesting AJ, et al. Among authors: klemm p. Mol Metab. 2022 Dec;66:101626. doi: 10.1016/j.molmet.2022.101626. Epub 2022 Nov 7. Mol Metab. 2022. PMID: 36356831 Free PMC article.
Nutrient-sensing AgRP neurons relay control of liver autophagy during energy deprivation.
Chen W, Mehlkop O, Scharn A, Nolte H, Klemm P, Henschke S, Steuernagel L, Sotelo-Hitschfeld T, Kaya E, Wunderlich CM, Langer T, Kononenko NL, Giavalisco P, Brüning JC. Chen W, et al. Among authors: klemm p. Cell Metab. 2023 May 2;35(5):786-806.e13. doi: 10.1016/j.cmet.2023.03.019. Epub 2023 Apr 18. Cell Metab. 2023. PMID: 37075752 Free PMC article.
361 results