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Isocitrate-to-SENP1 signaling amplifies insulin secretion and rescues dysfunctional β cells.
Ferdaoussi M, Dai X, Jensen MV, Wang R, Peterson BS, Huang C, Ilkayeva O, Smith N, Miller N, Hajmrle C, Spigelman AF, Wright RC, Plummer G, Suzuki K, Mackay JP, van de Bunt M, Gloyn AL, Ryan TE, Norquay LD, Brosnan MJ, Trimmer JK, Rolph TP, Kibbey RG, Manning Fox JE, Colmers WF, Shirihai OS, Neufer PD, Yeh ET, Newgard CB, MacDonald PE. Ferdaoussi M, et al. Among authors: suzuki k. J Clin Invest. 2015 Oct 1;125(10):3847-60. doi: 10.1172/JCI82498. Epub 2015 Sep 21. J Clin Invest. 2015. PMID: 26389676 Free PMC article.
Kv2.1 Clustering Contributes to Insulin Exocytosis and Rescues Human β-Cell Dysfunction.
Fu J, Dai X, Plummer G, Suzuki K, Bautista A, Githaka JM, Senior L, Jensen M, Greitzer-Antes D, Manning Fox JE, Gaisano HY, Newgard CB, Touret N, MacDonald PE. Fu J, et al. Among authors: suzuki k. Diabetes. 2017 Jul;66(7):1890-1900. doi: 10.2337/db16-1170. Epub 2017 Jun 12. Diabetes. 2017. PMID: 28607108 Free PMC article.
Zmiz1 is required for mature β-cell function and mass expansion upon high fat feeding.
Alghamdi TA, Krentz NAJ, Smith N, Spigelman AF, Rajesh V, Jha A, Ferdaoussi M, Suzuki K, Yang J, Manning Fox JE, Sun H, Sun Z, Gloyn AL, MacDonald PE. Alghamdi TA, et al. Among authors: suzuki k. Mol Metab. 2022 Dec;66:101621. doi: 10.1016/j.molmet.2022.101621. Epub 2022 Oct 26. Mol Metab. 2022. PMID: 36307047 Free PMC article.
A role and mechanism for redox sensing by SENP1 in β-cell responses to high fat feeding.
Lin H, Suzuki K, Smith N, Li X, Nalbach L, Fuentes S, Spigelman AF, Dai XQ, Bautista A, Ferdaoussi M, Aggarwal S, Pepper AR, Roma LP, Ampofo E, Li WH, MacDonald PE. Lin H, et al. Among authors: suzuki k. Nat Commun. 2024 Jan 6;15(1):334. doi: 10.1038/s41467-023-44589-x. Nat Commun. 2024. PMID: 38184650 Free PMC article.
19,599 results
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