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The Ccr4-Not complex monitors the translating ribosome for codon optimality.
Buschauer R, Matsuo Y, Sugiyama T, Chen YH, Alhusaini N, Sweet T, Ikeuchi K, Cheng J, Matsuki Y, Nobuta R, Gilmozzi A, Berninghausen O, Tesina P, Becker T, Coller J, Inada T, Beckmann R. Buschauer R, et al. Among authors: chen yh. Science. 2020 Apr 17;368(6488):eaay6912. doi: 10.1126/science.aay6912. Science. 2020. PMID: 32299921 Free PMC article.
Codon optimality is a major determinant of mRNA stability.
Presnyak V, Alhusaini N, Chen YH, Martin S, Morris N, Kline N, Olson S, Weinberg D, Baker KE, Graveley BR, Coller J. Presnyak V, et al. Among authors: chen yh. Cell. 2015 Mar 12;160(6):1111-24. doi: 10.1016/j.cell.2015.02.029. Cell. 2015. PMID: 25768907 Free PMC article.
A Universal Code for mRNA Stability?
Chen YH, Coller J. Chen YH, et al. Trends Genet. 2016 Nov;32(11):687-688. doi: 10.1016/j.tig.2016.08.007. Epub 2016 Sep 1. Trends Genet. 2016. PMID: 27594172 Free PMC article. Review.
Short poly(A) tails are a conserved feature of highly expressed genes.
Lima SA, Chipman LB, Nicholson AL, Chen YH, Yee BA, Yeo GW, Coller J, Pasquinelli AE. Lima SA, et al. Among authors: chen yh. Nat Struct Mol Biol. 2017 Dec;24(12):1057-1063. doi: 10.1038/nsmb.3499. Epub 2017 Nov 6. Nat Struct Mol Biol. 2017. PMID: 29106412 Free PMC article.
7,310 results