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Page 1
An in vivo platform to select and evolve aggregation-resistant proteins.
Ebo JS, Saunders JC, Devine PWA, Gordon AM, Warwick AS, Schiffrin B, Chin SE, England E, Button JD, Lloyd C, Bond NJ, Ashcroft AE, Radford SE, Lowe DC, Brockwell DJ. Ebo JS, et al. Among authors: devine pwa. Nat Commun. 2020 Apr 14;11(1):1816. doi: 10.1038/s41467-020-15667-1. Nat Commun. 2020. PMID: 32286330 Free PMC article.
Skp is a multivalent chaperone of outer-membrane proteins.
Schiffrin B, Calabrese AN, Devine PWA, Harris SA, Ashcroft AE, Brockwell DJ, Radford SE. Schiffrin B, et al. Among authors: devine pwa. Nat Struct Mol Biol. 2016 Sep;23(9):786-793. doi: 10.1038/nsmb.3266. Epub 2016 Jul 25. Nat Struct Mol Biol. 2016. PMID: 27455461 Free PMC article.
Engineering the surface properties of a human monoclonal antibody prevents self-association and rapid clearance in vivo.
Dobson CL, Devine PW, Phillips JJ, Higazi DR, Lloyd C, Popovic B, Arnold J, Buchanan A, Lewis A, Goodman J, van der Walle CF, Thornton P, Vinall L, Lowne D, Aagaard A, Olsson LL, Ridderstad Wollberg A, Welsh F, Karamanos TK, Pashley CL, Iadanza MG, Ranson NA, Ashcroft AE, Kippen AD, Vaughan TJ, Radford SE, Lowe DC. Dobson CL, et al. Sci Rep. 2016 Dec 20;6:38644. doi: 10.1038/srep38644. Sci Rep. 2016. PMID: 27995962 Free PMC article.
Interconversion of Unexpected Thiol States Affects the Stability, Structure, and Dynamics of Antibody Engineered for Site-Specific Conjugation.
Orozco CT, Edgeworth MJ, Devine PWA, Hines AR, Cornwell O, Thompson C, Wang X, Phillips JJ, Ravn P, Jackson SE, Bond NJ. Orozco CT, et al. Among authors: devine pwa. Bioconjug Chem. 2021 Aug 18;32(8):1834-1844. doi: 10.1021/acs.bioconjchem.1c00286. Epub 2021 Aug 9. Bioconjug Chem. 2021. PMID: 34369158 Free article.
Antisense oligonucleotide activity in tumour cells is influenced by intracellular LBPA distribution and extracellular vesicle recycling.
Kapustin AN, Davey P, Longmire D, Matthews C, Linnane E, Rustogi N, Stavrou M, Devine PWA, Bond NJ, Hanson L, Sonzini S, Revenko A, MacLeod AR, Ross S, Chiarparin E, Puri S. Kapustin AN, et al. Among authors: devine pwa. Commun Biol. 2021 Nov 1;4(1):1241. doi: 10.1038/s42003-021-02772-0. Commun Biol. 2021. PMID: 34725463 Free PMC article.
Mechanistic insights into the rational design of masked antibodies.
Orozco CT, Bersellini M, Irving LM, Howard WW, Hargreaves D, Devine PWA, Siouve E, Browne GJ, Bond NJ, Phillips JJ, Ravn P, Jackson SE. Orozco CT, et al. Among authors: devine pwa. MAbs. 2022 Jan-Dec;14(1):2095701. doi: 10.1080/19420862.2022.2095701. MAbs. 2022. PMID: 35799328 Free PMC article.
To 200,000 m/z and Beyond: Native Electron Capture Charge Reduction Mass Spectrometry Deconvolves Heterogeneous Signals in Large Biopharmaceutical Analytes.
Le Huray KIP, Wörner TP, Moreira T, Dembek M, Reinhardt-Szyba M, Devine PWA, Bond NJ, Fort KL, Makarov AA, Sobott F. Le Huray KIP, et al. Among authors: devine pwa. ACS Cent Sci. 2024 Jul 26;10(8):1548-1561. doi: 10.1021/acscentsci.4c00462. eCollection 2024 Aug 28. ACS Cent Sci. 2024. PMID: 39220705 Free PMC article.
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