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CTLA-4 and PD-1 dual blockade induces SIV reactivation without control of rebound after antiretroviral therapy interruption.
Harper J, Gordon S, Chan CN, Wang H, Lindemuth E, Galardi C, Falcinelli SD, Raines SLM, Read JL, Nguyen K, McGary CS, Nekorchuk M, Busman-Sahay K, Schawalder J, King C, Pino M, Micci L, Cervasi B, Jean S, Sanderson A, Johns B, Koblansky AA, Amrine-Madsen H, Lifson J, Margolis DM, Silvestri G, Bar KJ, Favre D, Estes JD, Paiardini M. Harper J, et al. Among authors: mcgary cs. Nat Med. 2020 Apr;26(4):519-528. doi: 10.1038/s41591-020-0782-y. Epub 2020 Mar 16. Nat Med. 2020. PMID: 32284611 Free PMC article.
CTLA-4+PD-1- Memory CD4+ T Cells Critically Contribute to Viral Persistence in Antiretroviral Therapy-Suppressed, SIV-Infected Rhesus Macaques.
McGary CS, Deleage C, Harper J, Micci L, Ribeiro SP, Paganini S, Kuri-Cervantes L, Benne C, Ryan ES, Balderas R, Jean S, Easley K, Marconi V, Silvestri G, Estes JD, Sekaly RP, Paiardini M. McGary CS, et al. Immunity. 2017 Oct 17;47(4):776-788.e5. doi: 10.1016/j.immuni.2017.09.018. Immunity. 2017. PMID: 29045906 Free PMC article.
Simian Immunodeficiency Virus Persistence in Cellular and Anatomic Reservoirs in Antiretroviral Therapy-Suppressed Infant Rhesus Macaques.
Mavigner M, Habib J, Deleage C, Rosen E, Mattingly C, Bricker K, Kashuba A, Amblard F, Schinazi RF, Lawson B, Vanderford TH, Jean S, Cohen J, McGary C, Paiardini M, Wood MP, Sodora DL, Silvestri G, Estes J, Chahroudi A. Mavigner M, et al. J Virol. 2018 Aug 29;92(18):e00562-18. doi: 10.1128/JVI.00562-18. Print 2018 Sep 15. J Virol. 2018. PMID: 29997216 Free PMC article.
Increased stability and limited proliferation of CD4+ central memory T cells differentiate nonprogressive simian immunodeficiency virus (SIV) infection of sooty mangabeys from progressive SIV infection of rhesus macaques.
McGary CS, Cervasi B, Chahroudi A, Micci L, Taaffe J, Meeker T, Silvestri G, Davenport MP, Paiardini M. McGary CS, et al. J Virol. 2014 Apr;88(8):4533-42. doi: 10.1128/JVI.03515-13. Epub 2014 Feb 5. J Virol. 2014. PMID: 24501416 Free PMC article.
Animal models for viral infection and cell exhaustion.
McGary CS, Silvestri G, Paiardini M. McGary CS, et al. Curr Opin HIV AIDS. 2014 Sep;9(5):492-9. doi: 10.1097/COH.0000000000000093. Curr Opin HIV AIDS. 2014. PMID: 25023622 Free PMC article. Review.
CD4 depletion in SIV-infected macaques results in macrophage and microglia infection with rapid turnover of infected cells.
Micci L, Alvarez X, Iriele RI, Ortiz AM, Ryan ES, McGary CS, Deleage C, McAtee BB, He T, Apetrei C, Easley K, Pahwa S, Collman RG, Derdeyn CA, Davenport MP, Estes JD, Silvestri G, Lackner AA, Paiardini M. Micci L, et al. Among authors: mcgary cs. PLoS Pathog. 2014 Oct 30;10(10):e1004467. doi: 10.1371/journal.ppat.1004467. eCollection 2014 Oct. PLoS Pathog. 2014. PMID: 25356757 Free PMC article.
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