January CT - Search Results

1

LUF7244 plus Dofetilide Rescues Aberrant K_v11.1 Trafficking and Produces Functional I_Kv11.1.

Qile M, Ji Y, Golden TD, Houtman MJC, Romunde F, Fransen D, van Ham WB, IJzerman AP, January CT, Heitman LH, Stary-Weinzinger A, Delisle BP, van der Heyden MAG. Qile M, et al. Among authors: january ct. Mol Pharmacol. 2020 Jun;97(6):355-364. doi: 10.1124/mol.119.118190. Epub 2020 Apr 2. Mol Pharmacol. 2020. PMID: 32241959

2

Thapsigargin selectively rescues the trafficking defective LQT2 channels G601S and F805C.

Delisle BP, Anderson CL, Balijepalli RC, Anson BD, Kamp TJ, January CT. Delisle BP, et al. Among authors: january ct. J Biol Chem. 2003 Sep 12;278(37):35749-54. doi: 10.1074/jbc.M305787200. Epub 2003 Jul 1. J Biol Chem. 2003. PMID: 12837749 Free article.

3

Biology of cardiac arrhythmias: ion channel protein trafficking.

Delisle BP, Anson BD, Rajamani S, January CT. Delisle BP, et al. Among authors: january ct. Circ Res. 2004 Jun 11;94(11):1418-28. doi: 10.1161/01.RES.0000128561.28701.ea. Circ Res. 2004. PMID: 15192037 Review.

4

Intragenic suppression of trafficking-defective KCNH2 channels associated with long QT syndrome.

Delisle BP, Slind JK, Kilby JA, Anderson CL, Anson BD, Balijepalli RC, Tester DJ, Ackerman MJ, Kamp TJ, January CT. Delisle BP, et al. Among authors: january ct. Mol Pharmacol. 2005 Jul;68(1):233-40. doi: 10.1124/mol.105.012914. Epub 2005 Apr 25. Mol Pharmacol. 2005. PMID: 15851652

5

Most LQT2 mutations reduce Kv11.1 (hERG) current by a class 2 (trafficking-deficient) mechanism.

Anderson CL, Delisle BP, Anson BD, Kilby JA, Will ML, Tester DJ, Gong Q, Zhou Z, Ackerman MJ, January CT. Anderson CL, et al. Among authors: january ct. Circulation. 2006 Jan 24;113(3):365-73. doi: 10.1161/CIRCULATIONAHA.105.570200. Circulation. 2006. PMID: 16432067

6

Trafficking-deficient hERG K⁺ channels linked to long QT syndrome are regulated by a microtubule-dependent quality control compartment in the ER.

Smith JL, McBride CM, Nataraj PS, Bartos DC, January CT, Delisle BP. Smith JL, et al. Among authors: january ct. Am J Physiol Cell Physiol. 2011 Jul;301(1):C75-85. doi: 10.1152/ajpcell.00494.2010. Epub 2011 Apr 13. Am J Physiol Cell Physiol. 2011. PMID: 21490315 Free PMC article.

7

Mechanism of loss of Kv11.1 K+ current in mutant T421M-Kv11.1-expressing rat ventricular myocytes: interaction of trafficking and gating.

Balijepalli SY, Lim E, Concannon SP, Chew CL, Holzem KE, Tester DJ, Ackerman MJ, Delisle BP, Balijepalli RC, January CT. Balijepalli SY, et al. Among authors: january ct. Circulation. 2012 Dec 11;126(24):2809-18. doi: 10.1161/CIRCULATIONAHA.112.118018. Epub 2012 Nov 6. Circulation. 2012. PMID: 23136156 Free PMC article.

8

Pharmacological correction of long QT-linked mutations in KCNH2 (hERG) increases the trafficking of Kv11.1 channels stored in the transitional endoplasmic reticulum.

Smith JL, Reloj AR, Nataraj PS, Bartos DC, Schroder EA, Moss AJ, Ohno S, Horie M, Anderson CL, January CT, Delisle BP. Smith JL, et al. Among authors: january ct. Am J Physiol Cell Physiol. 2013 Nov 1;305(9):C919-30. doi: 10.1152/ajpcell.00406.2012. Epub 2013 Jul 17. Am J Physiol Cell Physiol. 2013. PMID: 23864605 Free PMC article.

9

Large-scale mutational analysis of Kv11.1 reveals molecular insights into type 2 long QT syndrome.

Anderson CL, Kuzmicki CE, Childs RR, Hintz CJ, Delisle BP, January CT. Anderson CL, et al. Among authors: january ct. Nat Commun. 2014 Nov 24;5:5535. doi: 10.1038/ncomms6535. Nat Commun. 2014. PMID: 25417810 Free PMC article.

10

Kv11.1 (ERG1) K+ channels localize in cholesterol and sphingolipid enriched membranes and are modulated by membrane cholesterol.

Balijepalli RC, Delisle BP, Balijepalli SY, Foell JD, Slind JK, Kamp TJ, January CT. Balijepalli RC, et al. Among authors: january ct. Channels (Austin). 2007 Jul-Aug;1(4):263-72. doi: 10.4161/chan.4946. Epub 2007 Aug 27. Channels (Austin). 2007. PMID: 18708743

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