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Structure of a Blinkin-BUBR1 complex reveals an interaction crucial for kinetochore-mitotic checkpoint regulation via an unanticipated binding Site.
Bolanos-Garcia VM, Lischetti T, Matak-Vinković D, Cota E, Simpson PJ, Chirgadze DY, Spring DR, Robinson CV, Nilsson J, Blundell TL. Bolanos-Garcia VM, et al. Among authors: spring dr. Structure. 2011 Nov 9;19(11):1691-700. doi: 10.1016/j.str.2011.09.017. Epub 2011 Oct 13. Structure. 2011. PMID: 22000412 Free PMC article.
Demonstration of the utility of DOS-derived fragment libraries for rapid hit derivatisation in a multidirectional fashion.
Kidd SL, Fowler E, Reinhardt T, Compton T, Mateu N, Newman H, Bellini D, Talon R, McLoughlin J, Krojer T, Aimon A, Bradley A, Fairhead M, Brear P, Díaz-Sáez L, McAuley K, Sore HF, Madin A, O'Donovan DH, Huber KVM, Hyvönen M, von Delft F, Dowson CG, Spring DR. Kidd SL, et al. Among authors: spring dr. Chem Sci. 2020 May 14;11(39):10792-10801. doi: 10.1039/d0sc01232g. Chem Sci. 2020. PMID: 34094333 Free PMC article.
Selective Aurora A-TPX2 Interaction Inhibitors Have In Vivo Efficacy as Targeted Antimitotic Agents.
Stockwell SR, Scott DE, Fischer G, Guarino E, Rooney TPC, Feng TS, Moschetti T, Srinivasan R, Alza E, Asteian A, Dagostin C, Alcaide A, Rocaboy M, Blaszczyk B, Higueruelo A, Wang X, Rossmann M, Perrior TR, Blundell TL, Spring DR, McKenzie G, Abell C, Skidmore J, Venkitaraman AR, Hyvönen M. Stockwell SR, et al. Among authors: spring dr. J Med Chem. 2024 Sep 12;67(17):15521-15536. doi: 10.1021/acs.jmedchem.4c01165. Epub 2024 Aug 27. J Med Chem. 2024. PMID: 39190548 Free PMC article.
Fluorous tagged small molecule microarrays.
Nicholson RL, Ladlow ML, Spring DR. Nicholson RL, et al. Among authors: spring dr. Chem Commun (Camb). 2007 Oct 14;(38):3906-8. doi: 10.1039/b712906h. Epub 2007 Sep 4. Chem Commun (Camb). 2007. PMID: 17896028
3D small-molecule microarrays.
Marsden DM, Nicholson RL, Ladlow M, Spring DR. Marsden DM, et al. Among authors: spring dr. Chem Commun (Camb). 2009 Dec 14;(46):7107-9. doi: 10.1039/b913665g. Epub 2009 Sep 2. Chem Commun (Camb). 2009. PMID: 19920998
224 results