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Cell-Based Ligand Discovery for the ENL YEATS Domain.
Asiaban JN, Milosevich N, Chen E, Bishop TR, Wang J, Zhang Y, Ackerman CJ, Hampton EN, Young TS, Hull MV, Cravatt BF, Erb MA. Asiaban JN, et al. Among authors: zhang y. ACS Chem Biol. 2020 Apr 17;15(4):895-903. doi: 10.1021/acschembio.0c00124. Epub 2020 Mar 19. ACS Chem Biol. 2020. PMID: 32176478 Free PMC article.
A short ORF-encoded transcriptional regulator.
Koh M, Ahmad I, Ko Y, Zhang Y, Martinez TF, Diedrich JK, Chu Q, Moresco JJ, Erb MA, Saghatelian A, Schultz PG, Bollong MJ. Koh M, et al. Among authors: zhang y. Proc Natl Acad Sci U S A. 2021 Jan 26;118(4):e2021943118. doi: 10.1073/pnas.2021943118. Proc Natl Acad Sci U S A. 2021. PMID: 33468658 Free PMC article.
Acetyl-CoA biosynthesis drives resistance to histone acetyltransferase inhibition.
Bishop TR, Subramanian C, Bilotta EM, Garnar-Wortzel L, Ramos AR, Zhang Y, Asiaban JN, Ott CJ, Rock CO, Erb MA. Bishop TR, et al. Among authors: zhang y. Nat Chem Biol. 2023 Oct;19(10):1215-1222. doi: 10.1038/s41589-023-01320-7. Epub 2023 May 1. Nat Chem Biol. 2023. PMID: 37127754 Free PMC article.
Redirecting the pioneering function of FOXA1 with covalent small molecules.
Won SJ, Zhang Y, Reinhardt CJ, MacRae NS, DeMeester KE, Njomen E, Hargis LM, Remsberg JR, Melillo B, Cravatt BF, Erb MA. Won SJ, et al. Among authors: zhang y. bioRxiv [Preprint]. 2024 Mar 21:2024.03.21.586158. doi: 10.1101/2024.03.21.586158. bioRxiv. 2024. Update in: Mol Cell. 2024 Oct 9:S1097-2765(24)00780-9. doi: 10.1016/j.molcel.2024.09.024. PMID: 38562719 Free PMC article. Updated. Preprint.
Redirecting the pioneering function of FOXA1 with covalent small molecules.
Won SJ, Zhang Y, Reinhardt CJ, Hargis LM, MacRae NS, DeMeester KE, Njomen E, Remsberg JR, Melillo B, Cravatt BF, Erb MA. Won SJ, et al. Among authors: zhang y. Mol Cell. 2024 Oct 9:S1097-2765(24)00780-9. doi: 10.1016/j.molcel.2024.09.024. Online ahead of print. Mol Cell. 2024. PMID: 39413792
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