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Targeting Glycosylated PD-1 Induces Potent Antitumor Immunity.
Sun L, Li CW, Chung EM, Yang R, Kim YS, Park AH, Lai YJ, Yang Y, Wang YH, Liu J, Qiu Y, Khoo KH, Yao J, Hsu JL, Cha JH, Chan LC, Hsu JM, Lee HH, Yoo SS, Hung MC. Sun L, et al. Among authors: khoo kh. Cancer Res. 2020 Jun 1;80(11):2298-2310. doi: 10.1158/0008-5472.CAN-19-3133. Epub 2020 Mar 10. Cancer Res. 2020. PMID: 32156778 Free PMC article.
Glycosylation and stabilization of programmed death ligand-1 suppresses T-cell activity.
Li CW, Lim SO, Xia W, Lee HH, Chan LC, Kuo CW, Khoo KH, Chang SS, Cha JH, Kim T, Hsu JL, Wu Y, Hsu JM, Yamaguchi H, Ding Q, Wang Y, Yao J, Lee CC, Wu HJ, Sahin AA, Allison JP, Yu D, Hortobagyi GN, Hung MC. Li CW, et al. Among authors: khoo kh. Nat Commun. 2016 Aug 30;7:12632. doi: 10.1038/ncomms12632. Nat Commun. 2016. PMID: 27572267 Free PMC article.
Eradication of Triple-Negative Breast Cancer Cells by Targeting Glycosylated PD-L1.
Li CW, Lim SO, Chung EM, Kim YS, Park AH, Yao J, Cha JH, Xia W, Chan LC, Kim T, Chang SS, Lee HH, Chou CK, Liu YL, Yeh HC, Perillo EP, Dunn AK, Kuo CW, Khoo KH, Hsu JL, Wu Y, Hsu JM, Yamaguchi H, Huang TH, Sahin AA, Hortobagyi GN, Yoo SS, Hung MC. Li CW, et al. Among authors: khoo kh. Cancer Cell. 2018 Feb 12;33(2):187-201.e10. doi: 10.1016/j.ccell.2018.01.009. Cancer Cell. 2018. PMID: 29438695 Free PMC article.
STT3-dependent PD-L1 accumulation on cancer stem cells promotes immune evasion.
Hsu JM, Xia W, Hsu YH, Chan LC, Yu WH, Cha JH, Chen CT, Liao HW, Kuo CW, Khoo KH, Hsu JL, Li CW, Lim SO, Chang SS, Chen YC, Ren GX, Hung MC. Hsu JM, et al. Among authors: khoo kh. Nat Commun. 2018 May 15;9(1):1908. doi: 10.1038/s41467-018-04313-6. Nat Commun. 2018. PMID: 29765039 Free PMC article.
Metformin Promotes Antitumor Immunity via Endoplasmic-Reticulum-Associated Degradation of PD-L1.
Cha JH, Yang WH, Xia W, Wei Y, Chan LC, Lim SO, Li CW, Kim T, Chang SS, Lee HH, Hsu JL, Wang HL, Kuo CW, Chang WC, Hadad S, Purdie CA, McCoy AM, Cai S, Tu Y, Litton JK, Mittendorf EA, Moulder SL, Symmans WF, Thompson AM, Piwnica-Worms H, Chen CH, Khoo KH, Hung MC. Cha JH, et al. Among authors: khoo kh. Mol Cell. 2018 Aug 16;71(4):606-620.e7. doi: 10.1016/j.molcel.2018.07.030. Mol Cell. 2018. PMID: 30118680 Free PMC article.
Sialylation of CD55 by ST3GAL1 Facilitates Immune Evasion in Cancer.
Lin WD, Fan TC, Hung JT, Yeo HL, Wang SH, Kuo CW, Khoo KH, Pai LM, Yu J, Yu AL. Lin WD, et al. Among authors: khoo kh. Cancer Immunol Res. 2021 Jan;9(1):113-122. doi: 10.1158/2326-6066.CIR-20-0203. Epub 2020 Nov 11. Cancer Immunol Res. 2021. PMID: 33177111
Glycans on influenza hemagglutinin affect receptor binding and immune response.
Wang CC, Chen JR, Tseng YC, Hsu CH, Hung YF, Chen SW, Chen CM, Khoo KH, Cheng TJ, Cheng YS, Jan JT, Wu CY, Ma C, Wong CH. Wang CC, et al. Among authors: khoo kh. Proc Natl Acad Sci U S A. 2009 Oct 27;106(43):18137-42. doi: 10.1073/pnas.0909696106. Epub 2009 Oct 12. Proc Natl Acad Sci U S A. 2009. PMID: 19822741 Free PMC article.
293 results