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Immune Pharmacodynamic Responses of the Novel Cancer Immunotherapeutic Imprime PGG in Healthy Volunteers.
Bose N, Ottoson NR, Qiu X, Harrison B, Lowe JR, Uhlik MT, Rathmann BT, Kangas TO, Jordan LR, Ertelt KE, Jonas AB, Walsh RM, Chan ASH, Fulton RB, Leonardo SM, Fraser KA, Gorden KB, Matson MA, Graff JR, Huhn RD. Bose N, et al. Among authors: gorden kb. J Immunol. 2019 May 15;202(10):2945-2956. doi: 10.4049/jimmunol.1801533. Epub 2019 Apr 15. J Immunol. 2019. PMID: 30988115 Clinical Trial.
A randomized, open-label, multicenter, phase II study evaluating the efficacy and safety of BTH1677 (1,3-1,6 beta glucan; Imprime PGG) in combination with cetuximab and chemotherapy in patients with advanced non-small cell lung cancer.
Thomas M, Sadjadian P, Kollmeier J, Lowe J, Mattson P, Trout JR, Gargano M, Patchen ML, Walsh R, Beliveau M, Marier JF, Bose N, Gorden K, Schneller F 3rd. Thomas M, et al. Among authors: gorden k. Invest New Drugs. 2017 Jun;35(3):345-358. doi: 10.1007/s10637-017-0450-3. Epub 2017 Mar 16. Invest New Drugs. 2017. PMID: 28303530 Free PMC article. Clinical Trial.
Imprime PGG-Mediated Anti-Cancer Immune Activation Requires Immune Complex Formation.
Chan AS, Jonas AB, Qiu X, Ottoson NR, Walsh RM, Gorden KB, Harrison B, Maimonis PJ, Leonardo SM, Ertelt KE, Danielson ME, Michel KS, Nelson M, Graff JR, Patchen ML, Bose N. Chan AS, et al. Among authors: gorden kb. PLoS One. 2016 Nov 3;11(11):e0165909. doi: 10.1371/journal.pone.0165909. eCollection 2016. PLoS One. 2016. PMID: 27812183 Free PMC article.
Binding of Soluble Yeast β-Glucan to Human Neutrophils and Monocytes is Complement-Dependent.
Bose N, Chan AS, Guerrero F, Maristany CM, Qiu X, Walsh RM, Ertelt KE, Jonas AB, Gorden KB, Dudney CM, Wurst LR, Danielson ME, Elmasry N, Magee AS, Patchen ML, Vasilakos JP. Bose N, et al. Among authors: gorden kb. Front Immunol. 2013 Aug 12;4:230. doi: 10.3389/fimmu.2013.00230. eCollection 2013. Front Immunol. 2013. PMID: 23964276 Free PMC article.
21 results