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Massively parallel variant characterization identifies NUDT15 alleles associated with thiopurine toxicity.
Suiter CC, Moriyama T, Matreyek KA, Yang W, Scaletti ER, Nishii R, Yang W, Hoshitsuki K, Singh M, Trehan A, Parish C, Smith C, Li L, Bhojwani D, Yuen LYP, Li CK, Li CH, Yang YL, Walker GJ, Goodhand JR, Kennedy NA, Klussmann FA, Bhatia S, Relling MV, Kato M, Hori H, Bhatia P, Ahmad T, Yeoh AEJ, Stenmark P, Fowler DM, Yang JJ. Suiter CC, et al. Among authors: stenmark p. Proc Natl Acad Sci U S A. 2020 Mar 10;117(10):5394-5401. doi: 10.1073/pnas.1915680117. Epub 2020 Feb 24. Proc Natl Acad Sci U S A. 2020. PMID: 32094176 Free PMC article.
MutT homologue 1 (MTH1) removes N6-methyl-dATP from the dNTP pool.
Scaletti ER, Vallin KS, Bräutigam L, Sarno A, Warpman Berglund U, Helleday T, Stenmark P, Jemth AS. Scaletti ER, et al. Among authors: stenmark p. J Biol Chem. 2020 Apr 10;295(15):4761-4772. doi: 10.1074/jbc.RA120.012636. Epub 2020 Mar 6. J Biol Chem. 2020. PMID: 32144205 Free PMC article.
Crystal structures of NUDT15 variants enabled by a potent inhibitor reveal the structural basis for thiopurine sensitivity.
Rehling D, Zhang SM, Jemth AS, Koolmeister T, Throup A, Wallner O, Scaletti E, Moriyama T, Nishii R, Davies J, Desroses M, Rudd SG, Scobie M, Homan E, Berglund UW, Yang JJ, Helleday T, Stenmark P. Rehling D, et al. Among authors: stenmark p. J Biol Chem. 2021 Jan-Jun;296:100568. doi: 10.1016/j.jbc.2021.100568. Epub 2021 Mar 19. J Biol Chem. 2021. PMID: 33753169 Free PMC article.
113 results