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Host-mediated ubiquitination of a mycobacterial protein suppresses immunity.
Wang L, Wu J, Li J, Yang H, Tang T, Liang H, Zuo M, Wang J, Liu H, Liu F, Chen J, Liu Z, Wang Y, Peng C, Wu X, Zheng R, Huang X, Ran Y, Rao Z, Ge B. Wang L, et al. Among authors: wu x, wu j. Nature. 2020 Jan;577(7792):682-688. doi: 10.1038/s41586-019-1915-7. Epub 2020 Jan 15. Nature. 2020. PMID: 31942069
Genome-wide association study identifies two risk loci for tuberculosis in Han Chinese.
Zheng R, Li Z, He F, Liu H, Chen J, Chen J, Xie X, Zhou J, Chen H, Wu X, Wu J, Chen B, Liu Y, Cui H, Fan L, Sha W, Liu Y, Wang J, Huang X, Zhang L, Xu F, Wang J, Feng Y, Qin L, Yang H, Liu Z, Cui Z, Liu F, Chen X, Gao S, Sun S, Shi Y, Ge B. Zheng R, et al. Among authors: wu x, wu j. Nat Commun. 2018 Oct 4;9(1):4072. doi: 10.1038/s41467-018-06539-w. Nat Commun. 2018. PMID: 30287856 Free PMC article.
Nuclear cGAS suppresses DNA repair and promotes tumorigenesis.
Liu H, Zhang H, Wu X, Ma D, Wu J, Wang L, Jiang Y, Fei Y, Zhu C, Tan R, Jungblut P, Pei G, Dorhoi A, Yan Q, Zhang F, Zheng R, Liu S, Liang H, Liu Z, Yang H, Chen J, Wang P, Tang T, Peng W, Hu Z, Xu Z, Huang X, Wang J, Li H, Zhou Y, Liu F, Yan D, Kaufmann SHE, Chen C, Mao Z, Ge B. Liu H, et al. Among authors: wu x, wu j. Nature. 2018 Nov;563(7729):131-136. doi: 10.1038/s41586-018-0629-6. Epub 2018 Oct 24. Nature. 2018. PMID: 30356214
cGAS facilitates sensing of extracellular cyclic dinucleotides to activate innate immunity.
Liu H, Moura-Alves P, Pei G, Mollenkopf HJ, Hurwitz R, Wu X, Wang F, Liu S, Ma M, Fei Y, Zhu C, Koehler AB, Oberbeck-Mueller D, Hahnke K, Klemm M, Guhlich-Bornhof U, Ge B, Tuukkanen A, Kolbe M, Dorhoi A, Kaufmann SH. Liu H, et al. Among authors: wu x. EMBO Rep. 2019 Apr;20(4):e46293. doi: 10.15252/embr.201846293. Epub 2019 Mar 14. EMBO Rep. 2019. PMID: 30872316 Free PMC article.
Oxidization of TGFβ-activated kinase by MPT53 is required for immunity to Mycobacterium tuberculosis.
Wang L, Liu Z, Wang J, Liu H, Wu J, Tang T, Li H, Yang H, Qin L, Ma D, Chen J, Liu F, Wang P, Zheng R, Song P, Zhou Y, Cui Z, Wu X, Huang X, Liang H, Zhang S, Cao J, Wu C, Chen Y, Su D, Chen X, Zeng G, Ge B. Wang L, et al. Among authors: wu x, wu c, wu j. Nat Microbiol. 2019 Aug;4(8):1378-1388. doi: 10.1038/s41564-019-0436-3. Epub 2019 May 20. Nat Microbiol. 2019. PMID: 31110366
CGAS is a micronucleophagy receptor for the clearance of micronuclei.
Zhao M, Wang F, Wu J, Cheng Y, Cao Y, Wu X, Ma M, Tang F, Liu Z, Liu H, Ge B. Zhao M, et al. Among authors: wu x, wu j. Autophagy. 2021 Dec;17(12):3976-3991. doi: 10.1080/15548627.2021.1899440. Epub 2021 Mar 22. Autophagy. 2021. PMID: 33752561 Free PMC article.
Sensing of mycobacterial arabinogalactan by galectin-9 exacerbates mycobacterial infection.
Wu X, Wu Y, Zheng R, Tang F, Qin L, Lai D, Zhang L, Chen L, Yan B, Yang H, Wang Y, Li F, Zhang J, Wang F, Wang L, Cao Y, Ma M, Liu Z, Chen J, Huang X, Wang J, Jin R, Wang P, Sun Q, Sha W, Lyu L, Moura-Alves P, Dorhoi A, Pei G, Zhang P, Chen J, Gao S, Randow F, Zeng G, Chen C, Ye XS, Kaufmann SHE, Liu H, Ge B. Wu X, et al. Among authors: wu y. EMBO Rep. 2021 Jul 5;22(7):e51678. doi: 10.15252/embr.202051678. Epub 2021 May 13. EMBO Rep. 2021. PMID: 33987949 Free PMC article.
Interception of host fatty acid metabolism by mycobacteria under hypoxia to suppress anti-TB immunity.
Yang H, Wang F, Guo X, Liu F, Liu Z, Wu X, Zhao M, Ma M, Liu H, Qin L, Wang L, Tang T, Sha W, Wang Y, Chen J, Huang X, Wang J, Peng C, Zheng R, Tang F, Zhang L, Wu C, Oehlers SH, Song Z, She J, Feng H, Xie X, Ge B. Yang H, et al. Among authors: wu x, wu c. Cell Discov. 2021 Oct 5;7(1):90. doi: 10.1038/s41421-021-00301-1. Cell Discov. 2021. PMID: 34608123 Free PMC article.
CDK inhibitor Palbociclib targets STING to alleviate autoinflammation.
Gao J, Zheng M, Wu X, Zhang H, Su H, Dang Y, Ma M, Wang F, Xu J, Chen L, Liu T, Chen J, Zhang F, Yang L, Xu Q, Hu X, Wang H, Fei Y, Chen C, Liu H. Gao J, et al. Among authors: wu x. EMBO Rep. 2022 Jun 7;23(6):e53932. doi: 10.15252/embr.202153932. Epub 2022 Apr 11. EMBO Rep. 2022. PMID: 35403787 Free PMC article.
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