Lawton LN - Search Results

1

ASCL1 is a MYCN- and LMO1-dependent member of the adrenergic neuroblastoma core regulatory circuitry.

Wang L, Tan TK, Durbin AD, Zimmerman MW, Abraham BJ, Tan SH, Ngoc PCT, Weichert-Leahey N, Akahane K, Lawton LN, Rokita JL, Maris JM, Young RA, Look AT, Sanda T. Wang L, et al. Among authors: lawton ln. Nat Commun. 2019 Dec 9;10(1):5622. doi: 10.1038/s41467-019-13515-5. Nat Commun. 2019. PMID: 31819055 Free PMC article.

2

Aberrant chromatin at genes encoding stem cell regulators in human mixed-lineage leukemia.

Guenther MG, Lawton LN, Rozovskaia T, Frampton GM, Levine SS, Volkert TL, Croce CM, Nakamura T, Canaani E, Young RA. Guenther MG, et al. Among authors: lawton ln. Genes Dev. 2008 Dec 15;22(24):3403-8. doi: 10.1101/gad.1741408. Genes Dev. 2008. PMID: 19141473 Free PMC article.

3

Densely interconnected transcriptional circuits control cell states in human hematopoiesis.

Novershtern N, Subramanian A, Lawton LN, Mak RH, Haining WN, McConkey ME, Habib N, Yosef N, Chang CY, Shay T, Frampton GM, Drake AC, Leskov I, Nilsson B, Preffer F, Dombkowski D, Evans JW, Liefeld T, Smutko JS, Chen J, Friedman N, Young RA, Golub TR, Regev A, Ebert BL. Novershtern N, et al. Among authors: lawton ln. Cell. 2011 Jan 21;144(2):296-309. doi: 10.1016/j.cell.2011.01.004. Cell. 2011. PMID: 21241896 Free PMC article.

4

Lineage regulators direct BMP and Wnt pathways to cell-specific programs during differentiation and regeneration.

Trompouki E, Bowman TV, Lawton LN, Fan ZP, Wu DC, DiBiase A, Martin CS, Cech JN, Sessa AK, Leblanc JL, Li P, Durand EM, Mosimann C, Heffner GC, Daley GQ, Paulson RF, Young RA, Zon LI. Trompouki E, et al. Among authors: lawton ln. Cell. 2011 Oct 28;147(3):577-89. doi: 10.1016/j.cell.2011.09.044. Cell. 2011. PMID: 22036566 Free PMC article.

5

Core transcriptional regulatory circuit controlled by the TAL1 complex in human T cell acute lymphoblastic leukemia.

Sanda T, Lawton LN, Barrasa MI, Fan ZP, Kohlhammer H, Gutierrez A, Ma W, Tatarek J, Ahn Y, Kelliher MA, Jamieson CH, Staudt LM, Young RA, Look AT. Sanda T, et al. Among authors: lawton ln. Cancer Cell. 2012 Aug 14;22(2):209-21. doi: 10.1016/j.ccr.2012.06.007. Cancer Cell. 2012. PMID: 22897851 Free PMC article.

6

The TAL1 complex targets the FBXW7 tumor suppressor by activating miR-223 in human T cell acute lymphoblastic leukemia.

Mansour MR, Sanda T, Lawton LN, Li X, Kreslavsky T, Novina CD, Brand M, Gutierrez A, Kelliher MA, Jamieson CH, von Boehmer H, Young RA, Look AT. Mansour MR, et al. Among authors: lawton ln. J Exp Med. 2013 Jul 29;210(8):1545-57. doi: 10.1084/jem.20122516. Epub 2013 Jul 15. J Exp Med. 2013. PMID: 23857984 Free PMC article.

7

Oncogene regulation. An oncogenic super-enhancer formed through somatic mutation of a noncoding intergenic element.

Mansour MR, Abraham BJ, Anders L, Berezovskaya A, Gutierrez A, Durbin AD, Etchin J, Lawton L, Sallan SE, Silverman LB, Loh ML, Hunger SP, Sanda T, Young RA, Look AT. Mansour MR, et al. Science. 2014 Dec 12;346(6215):1373-7. doi: 10.1126/science.1259037. Epub 2014 Nov 13. Science. 2014. PMID: 25394790 Free PMC article.

8

A genome-scale in vivo loss-of-function screen identifies Phf6 as a lineage-specific regulator of leukemia cell growth.

Meacham CE, Lawton LN, Soto-Feliciano YM, Pritchard JR, Joughin BA, Ehrenberger T, Fenouille N, Zuber J, Williams RT, Young RA, Hemann MT. Meacham CE, et al. Among authors: lawton ln. Genes Dev. 2015 Mar 1;29(5):483-8. doi: 10.1101/gad.254151.114. Genes Dev. 2015. PMID: 25737277 Free PMC article.

9

TRIB2 reinforces the oncogenic transcriptional program controlled by the TAL1 complex in T-cell acute lymphoblastic leukemia.

Tan SH, Yam AW, Lawton LN, Wong RW, Young RA, Look AT, Sanda T. Tan SH, et al. Among authors: lawton ln. Leukemia. 2016 Apr;30(4):959-62. doi: 10.1038/leu.2015.195. Epub 2015 Jul 23. Leukemia. 2016. PMID: 26202930 Free PMC article. No abstract available.

10

ARID5B as a critical downstream target of the TAL1 complex that activates the oncogenic transcriptional program and promotes T-cell leukemogenesis.

Leong WZ, Tan SH, Ngoc PCT, Amanda S, Yam AWY, Liau WS, Gong Z, Lawton LN, Tenen DG, Sanda T. Leong WZ, et al. Among authors: lawton ln. Genes Dev. 2017 Dec 1;31(23-24):2343-2360. doi: 10.1101/gad.302646.117. Epub 2018 Jan 11. Genes Dev. 2017. PMID: 29326336 Free PMC article.

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