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Structural attributes influencing unbound tissue distribution.
Orozco CC, Atkinson K, Ryu S, Chang G, Keefer C, Lin J, Riccardi K, Mongillo RK, Tess D, Filipski KJ, Kalgutkar AS, Litchfield J, Scott D, Di L. Orozco CC, et al. Among authors: scott d. Eur J Med Chem. 2020 Jan 1;185:111813. doi: 10.1016/j.ejmech.2019.111813. Epub 2019 Oct 28. Eur J Med Chem. 2020. PMID: 31732255
Discovery of N-benzyl-2-[(4S)-4-(1H-indol-3-ylmethyl)-5-oxo-1-phenyl-4,5-dihydro-6H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-6-yl]-N-isopropylacetamide, an orally active, gut-selective CCK1 receptor agonist for the potential treatment of obesity.
Elliott RL, Cameron KO, Chin JE, Bartlett JA, Beretta EE, Chen Y, Jardine Pda S, Dubins JS, Gillaspy ML, Hargrove DM, Kalgutkar AS, LaFlamme JA, Lame ME, Martin KA, Maurer TS, Nardone NA, Oliver RM, Scott DO, Sun D, Swick AG, Trebino CE, Zhang Y. Elliott RL, et al. Among authors: scott do. Bioorg Med Chem Lett. 2010 Nov 15;20(22):6797-801. doi: 10.1016/j.bmcl.2010.08.115. Epub 2010 Sep 28. Bioorg Med Chem Lett. 2010. PMID: 20851601
Species independence in brain tissue binding using brain homogenates.
Di L, Umland JP, Chang G, Huang Y, Lin Z, Scott DO, Troutman MD, Liston TE. Di L, et al. Among authors: scott do. Drug Metab Dispos. 2011 Jul;39(7):1270-7. doi: 10.1124/dmd.111.038778. Epub 2011 Apr 7. Drug Metab Dispos. 2011. PMID: 21474681
A new chemical tool for exploring the physiological function of the PDE2 isozyme.
Chambers RJ, Abrams K, Garceau NY, Kamath AV, Manley CM, Lilley SC, Otte DA, Scott DO, Sheils AL, Tess DA, Vellekoop AS, Zhang Y, Lam KT. Chambers RJ, et al. Bioorg Med Chem Lett. 2006 Jan 15;16(2):307-10. doi: 10.1016/j.bmcl.2005.10.005. Epub 2005 Nov 3. Bioorg Med Chem Lett. 2006. PMID: 16275071
6,595 results