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Page 1
Enzymatic Preparation of 2'-5',3'-5'-Cyclic Dinucleotides, Their Binding Properties to Stimulator of Interferon Genes Adaptor Protein, and Structure/Activity Correlations.
Novotná B, Vaneková L, Zavřel M, Buděšínský M, Dejmek M, Smola M, Gutten O, Tehrani ZA, Pimková Polidarová M, Brázdová A, Liboska R, Štěpánek I, Vavřina Z, Jandušík T, Nencka R, Rulíšek L, Bouřa E, Brynda J, Páv O, Birkuš G. Novotná B, et al. Among authors: brazdova a. J Med Chem. 2019 Dec 12;62(23):10676-10690. doi: 10.1021/acs.jmedchem.9b01062. Epub 2019 Nov 27. J Med Chem. 2019. PMID: 31715099
Synthesis and Biological Evaluation of Phosphoester and Phosphorothioate Prodrugs of STING Agonist 3',3'-c-Di(2'F,2'dAMP).
Pimková Polidarová M, Břehová P, Kaiser MM, Smola M, Dračínský M, Smith J, Marek A, Dejmek M, Šála M, Gutten O, Rulíšek L, Novotná B, Brázdová A, Janeba Z, Nencka R, Boura E, Páv O, Birkuš G. Pimková Polidarová M, et al. Among authors: brazdova a. J Med Chem. 2021 Jun 10;64(11):7596-7616. doi: 10.1021/acs.jmedchem.1c00301. Epub 2021 May 21. J Med Chem. 2021. PMID: 34019405
Discovery of isonucleotidic CDNs as potent STING agonists with immunomodulatory potential.
Dejmek M, Šála M, Brazdova A, Vanekova L, Smola M, Klíma M, Břehová P, Buděšínský M, Dračínský M, Procházková E, Zavřel M, Šimák O, Páv O, Boura E, Birkuš G, Nencka R. Dejmek M, et al. Among authors: brazdova a. Structure. 2022 Aug 4;30(8):1146-1156.e11. doi: 10.1016/j.str.2022.05.012. Epub 2022 Jun 10. Structure. 2022. PMID: 35690061 Free article.
Vinylphosphonate-based cyclic dinucleotides enhance STING-mediated cancer immunotherapy.
Dejmek M, Brazdova A, Otava T, Polidarova MP, Klíma M, Smola M, Vavrina Z, Buděšínský M, Dračínský M, Liboska R, Boura E, Birkuš G, Nencka R. Dejmek M, et al. Among authors: brazdova a. Eur J Med Chem. 2023 Nov 5;259:115685. doi: 10.1016/j.ejmech.2023.115685. Epub 2023 Jul 26. Eur J Med Chem. 2023. PMID: 37567057 Free article.
TMEM70 facilitates biogenesis of mammalian ATP synthase by promoting subunit c incorporation into the rotor structure of the enzyme.
Kovalčíkova J, Vrbacký M, Pecina P, Tauchmannová K, Nůsková H, Kaplanová V, Brázdová A, Alán L, Eliáš J, Čunátová K, Kořínek V, Sedlacek R, Mráček T, Houštěk J. Kovalčíkova J, et al. Among authors: brazdova a. FASEB J. 2019 Dec;33(12):14103-14117. doi: 10.1096/fj.201900685RR. Epub 2019 Oct 25. FASEB J. 2019. PMID: 31652072
TMEM70 absence causes severe ATP-synthase deficiency and leads to a neonatal mitochondrial encephalocardiomyopathy in humans. However, the exact biochemical function of TMEM70 remains unknown. ...-Kovalcikova, J., Vrbacky, M., Pecina, P., Tauchmannova, K., Nuskova, H., Kap …
TMEM70 absence causes severe ATP-synthase deficiency and leads to a neonatal mitochondrial encephalocardiomyopathy in humans. However …
21 results