Matherly LH - Search Results

1

Cellular Pharmacodynamics of a Novel Pyrrolo[3,2-d]pyrimidine Inhibitor Targeting Mitochondrial and Cytosolic One-Carbon Metabolism.

Dekhne AS, Ning C, Nayeen MJ, Shah K, Kalpage H, Frühauf J, Wallace-Povirk A, O'Connor C, Hou Z, Kim S, Hüttemann M, Gangjee A, Matherly LH. Dekhne AS, et al. Among authors: matherly lh. Mol Pharmacol. 2020 Jan;97(1):9-22. doi: 10.1124/mol.119.117937. Epub 2019 Nov 9. Mol Pharmacol. 2020. PMID: 31707355 Free PMC article.

2

Evidence for a localized conversion of endogenous tetrahydrofolate cofactors to dihydrofolate as an important element in antifolate action in murine leukemia cells.

Matherly LH, Muench SP. Matherly LH, et al. Biochem Pharmacol. 1990 Jun 15;39(12):2005-14. doi: 10.1016/0006-2952(90)90622-r. Biochem Pharmacol. 1990. PMID: 2141258

3

Localization of a substrate binding domain of the human reduced folate carrier to transmembrane domain 11 by radioaffinity labeling and cysteine-substituted accessibility methods.

Hou Z, Stapels SE, Haska CL, Matherly LH. Hou Z, et al. Among authors: matherly lh. J Biol Chem. 2005 Oct 28;280(43):36206-13. doi: 10.1074/jbc.M507295200. Epub 2005 Aug 22. J Biol Chem. 2005. PMID: 16115875 Free article.

4

Transmembrane domains 4, 5, 7, 8, and 10 of the human reduced folate carrier are important structural or functional components of the transmembrane channel for folate substrates.

Hou Z, Ye J, Haska CL, Matherly LH. Hou Z, et al. Among authors: matherly lh. J Biol Chem. 2006 Nov 3;281(44):33588-96. doi: 10.1074/jbc.M607049200. Epub 2006 Aug 21. J Biol Chem. 2006. PMID: 16923800 Free article.

5

Human reduced folate carrier: translation of basic biology to cancer etiology and therapy.

Matherly LH, Hou Z, Deng Y. Matherly LH, et al. Cancer Metastasis Rev. 2007 Mar;26(1):111-28. doi: 10.1007/s10555-007-9046-2. Cancer Metastasis Rev. 2007. PMID: 17334909 Review.

6

Role of lysine 411 in substrate carboxyl group binding to the human reduced folate carrier, as determined by site-directed mutagenesis and affinity inhibition.

Deng Y, Hou Z, Wang L, Cherian C, Wu J, Gangjee A, Matherly LH. Deng Y, et al. Among authors: matherly lh. Mol Pharmacol. 2008 Apr;73(4):1274-81. doi: 10.1124/mol.107.043190. Epub 2008 Jan 8. Mol Pharmacol. 2008. PMID: 18182479 Free PMC article.

7

Synthesis and discovery of high affinity folate receptor-specific glycinamide ribonucleotide formyltransferase inhibitors with antitumor activity.

Deng Y, Wang Y, Cherian C, Hou Z, Buck SA, Matherly LH, Gangjee A. Deng Y, et al. Among authors: matherly lh. J Med Chem. 2008 Aug 28;51(16):5052-63. doi: 10.1021/jm8003366. Epub 2008 Aug 5. J Med Chem. 2008. PMID: 18680275 Free PMC article.

8

Structure and function of the reduced folate carrier a paradigm of a major facilitator superfamily mammalian nutrient transporter.

Matherly LH, Hou Z. Matherly LH, et al. Vitam Horm. 2008;79:145-84. doi: 10.1016/S0083-6729(08)00405-6. Vitam Horm. 2008. PMID: 18804694 Free PMC article.

9

Oligomeric structure of the human reduced folate carrier: identification of homo-oligomers and dominant-negative effects on carrier expression and function.

Hou Z, Matherly LH. Hou Z, et al. Among authors: matherly lh. J Biol Chem. 2009 Jan 30;284(5):3285-3293. doi: 10.1074/jbc.M807206200. Epub 2008 Nov 19. J Biol Chem. 2009. PMID: 19019821 Free PMC article.

10

Synthesis and biological activity of a novel series of 6-substituted thieno[2,3-d]pyrimidine antifolate inhibitors of purine biosynthesis with selectivity for high affinity folate receptors over the reduced folate carrier and proton-coupled folate transporter for cellular entry.

Deng Y, Zhou X, Kugel Desmoulin S, Wu J, Cherian C, Hou Z, Matherly LH, Gangjee A. Deng Y, et al. Among authors: matherly lh. J Med Chem. 2009 May 14;52(9):2940-51. doi: 10.1021/jm8011323. J Med Chem. 2009. PMID: 19371039 Free PMC article.

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