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A MultiTEP platform-based epitope vaccine targeting the phosphatase activating domain (PAD) of tau: therapeutic efficacy in PS19 mice.
Hovakimyan A, Antonyan T, Shabestari SK, Svystun O, Chailyan G, Coburn MA, Carlen-Jones W, Petrushina I, Chadarevian JP, Zagorski K, Petrovsky N, Cribbs DH, Agadjanyan MG, Ghochikyan A, Davtyan H. Hovakimyan A, et al. Among authors: petrushina i. Sci Rep. 2019 Oct 29;9(1):15455. doi: 10.1038/s41598-019-51809-2. Sci Rep. 2019. PMID: 31664089 Free PMC article.
Immunization with a vaccine that combines the expression of MUC1 and B7 co-stimulatory molecules prolongs the survival of mice and delays the appearance of mouse mammary tumors.
Vasilevko V, Ghochikyan A, Sadzikava N, Petrushina I, Tran M, Cohen EP, Kesslak PJ, Cribbs DH, Nicolson GL, Agadjanyan MG. Vasilevko V, et al. Among authors: petrushina i. Clin Exp Metastasis. 2003;20(6):489-98. doi: 10.1023/a:1025802610724. Clin Exp Metastasis. 2003. PMID: 14598882
Mimotopes of conformational epitopes in fibrillar beta-amyloid.
Gevorkian G, Petrushina I, Manoutcharian K, Ghochikyan A, Acero G, Vasilevko V, Cribbs DH, Agadjanyan MG. Gevorkian G, et al. Among authors: petrushina i. J Neuroimmunol. 2004 Nov;156(1-2):10-20. doi: 10.1016/j.jneuroim.2004.06.004. J Neuroimmunol. 2004. PMID: 15465592
Anti-A beta 1-11 antibody binds to different beta-amyloid species, inhibits fibril formation, and disaggregates preformed fibrils but not the most toxic oligomers.
Mamikonyan G, Necula M, Mkrtichyan M, Ghochikyan A, Petrushina I, Movsesyan N, Mina E, Kiyatkin A, Glabe CG, Cribbs DH, Agadjanyan MG. Mamikonyan G, et al. Among authors: petrushina i. J Biol Chem. 2007 Aug 3;282(31):22376-86. doi: 10.1074/jbc.M700088200. Epub 2007 Jun 1. J Biol Chem. 2007. PMID: 17545160 Free PMC article.
48 results