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Page 1
Aspartate/asparagine-β-hydroxylase crystal structures reveal an unexpected epidermal growth factor-like domain substrate disulfide pattern.
Pfeffer I, Brewitz L, Krojer T, Jensen SA, Kochan GT, Kershaw NJ, Hewitson KS, McNeill LA, Kramer H, Münzel M, Hopkinson RJ, Oppermann U, Handford PA, McDonough MA, Schofield CJ. Pfeffer I, et al. Among authors: hewitson ks. Nat Commun. 2019 Oct 28;10(1):4910. doi: 10.1038/s41467-019-12711-7. Nat Commun. 2019. PMID: 31659163 Free PMC article.
The HIF pathway as a therapeutic target.
Hewitson KS, Schofield CJ. Hewitson KS, et al. Drug Discov Today. 2004 Aug 15;9(16):704-11. doi: 10.1016/S1359-6446(04)03202-7. Drug Discov Today. 2004. PMID: 15341784 Review.
Selective inhibition of factor inhibiting hypoxia-inducible factor.
McDonough MA, McNeill LA, Tilliet M, Papamicaël CA, Chen QY, Banerji B, Hewitson KS, Schofield CJ. McDonough MA, et al. Among authors: hewitson ks. J Am Chem Soc. 2005 Jun 1;127(21):7680-1. doi: 10.1021/ja050841b. J Am Chem Soc. 2005. PMID: 15913349
Cellular oxygen sensing: Crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2).
McDonough MA, Li V, Flashman E, Chowdhury R, Mohr C, Liénard BM, Zondlo J, Oldham NJ, Clifton IJ, Lewis J, McNeill LA, Kurzeja RJ, Hewitson KS, Yang E, Jordan S, Syed RS, Schofield CJ. McDonough MA, et al. Among authors: hewitson ks. Proc Natl Acad Sci U S A. 2006 Jun 27;103(26):9814-9. doi: 10.1073/pnas.0601283103. Epub 2006 Jun 16. Proc Natl Acad Sci U S A. 2006. PMID: 16782814 Free PMC article.
The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase.
Gerken T, Girard CA, Tung YC, Webby CJ, Saudek V, Hewitson KS, Yeo GS, McDonough MA, Cunliffe S, McNeill LA, Galvanovskis J, Rorsman P, Robins P, Prieur X, Coll AP, Ma M, Jovanovic Z, Farooqi IS, Sedgwick B, Barroso I, Lindahl T, Ponting CP, Ashcroft FM, O'Rahilly S, Schofield CJ. Gerken T, et al. Among authors: hewitson ks. Science. 2007 Nov 30;318(5855):1469-72. doi: 10.1126/science.1151710. Epub 2007 Nov 8. Science. 2007. PMID: 17991826 Free PMC article.
Kinetic rationale for selectivity toward N- and C-terminal oxygen-dependent degradation domain substrates mediated by a loop region of hypoxia-inducible factor prolyl hydroxylases.
Flashman E, Bagg EA, Chowdhury R, Mecinović J, Loenarz C, McDonough MA, Hewitson KS, Schofield CJ. Flashman E, et al. Among authors: hewitson ks. J Biol Chem. 2008 Feb 15;283(7):3808-15. doi: 10.1074/jbc.M707411200. Epub 2007 Dec 5. J Biol Chem. 2008. PMID: 18063574 Free article.
47 results