Yarov-Yarovoy V - Search Results

1

The Trials and Tribulations of Structure Assisted Design of K_Ca Channel Activators.

Shim H, Brown BM, Singh L, Singh V, Fettinger JC, Yarov-Yarovoy V, Wulff H. Shim H, et al. Front Pharmacol. 2019 Sep 20;10:972. doi: 10.3389/fphar.2019.00972. eCollection 2019. Front Pharmacol. 2019. PMID: 31616290 Free PMC article.

2

Harnessing AlphaFold to reveal hERG channel conformational state secrets.

Ngo K, Yang PC, Yarov-Yarovoy V, Clancy CE, Vorobyov I. Ngo K, et al. Among authors: yarov yarovoy v. bioRxiv [Preprint]. 2024 Oct 24:2024.01.27.577468. doi: 10.1101/2024.01.27.577468. bioRxiv. 2024. PMID: 38352360 Free PMC article. Preprint.

3

TRPV1 Opening is Stabilized Equally by Its Four Subunits.

Li S, Nguyen PT, Vu S, Yarov-Yarovoy V, Zheng J. Li S, et al. bioRxiv [Preprint]. 2023 Jan 27:2023.01.26.525787. doi: 10.1101/2023.01.26.525787. bioRxiv. 2023. Update in: J Biol Chem. 2023 Jun;299(6):104828. doi: 10.1016/j.jbc.2023.104828. PMID: 36747729 Free PMC article. Updated. Preprint.

4

Channels: Sticking to nooks and crannies.

Wulff H, Yarov-Yarovoy V. Wulff H, et al. Nat Chem Biol. 2013 Aug;9(8):473-4. doi: 10.1038/nchembio.1292. Nat Chem Biol. 2013. PMID: 23868316

5

Structural Insights into the Atomistic Mechanisms of Action of Small Molecule Inhibitors Targeting the KCa3.1 Channel Pore.

Nguyen HM, Singh V, Pressly B, Jenkins DP, Wulff H, Yarov-Yarovoy V. Nguyen HM, et al. Mol Pharmacol. 2017 Apr;91(4):392-402. doi: 10.1124/mol.116.108068. Epub 2017 Jan 26. Mol Pharmacol. 2017. PMID: 28126850 Free PMC article.

6

Structural Determinants for the Selectivity of the Positive KCa3.1 Gating Modulator 5-Methylnaphtho[2,1-d]oxazol-2-amine (SKA-121).

Brown BM, Shim H, Zhang M, Yarov-Yarovoy V, Wulff H. Brown BM, et al. Mol Pharmacol. 2017 Oct;92(4):469-480. doi: 10.1124/mol.117.109421. Epub 2017 Jul 31. Mol Pharmacol. 2017. PMID: 28760780 Free PMC article.

7

Antibodies and venom peptides: new modalities for ion channels.

Wulff H, Christophersen P, Colussi P, Chandy KG, Yarov-Yarovoy V. Wulff H, et al. Nat Rev Drug Discov. 2019 May;18(5):339-357. doi: 10.1038/s41573-019-0013-8. Nat Rev Drug Discov. 2019. PMID: 30728472 Free PMC article. Review.

8

Gating Properties of Mutant Sodium Channels and Responses to Sodium Current Inhibitors Predict Mexiletine-Sensitive Mutations of Long QT Syndrome 3.

Li G, Woltz RL, Wang CY, Ren L, He PX, Yu SD, Liu XQ, Yarov-Yarovoy V, Hu D, Chiamvimonvat N, Wu L. Li G, et al. Front Pharmacol. 2020 Aug 4;11:1182. doi: 10.3389/fphar.2020.01182. eCollection 2020. Front Pharmacol. 2020. PMID: 32848785 Free PMC article.

9

New capsaicin analogs as molecular rulers to define the permissive conformation of the mouse TRPV1 ligand-binding pocket.

Vu S, Singh V, Wulff H, Yarov-Yarovoy V, Zheng J. Vu S, et al. Elife. 2020 Nov 9;9:e62039. doi: 10.7554/eLife.62039. Elife. 2020. PMID: 33164749 Free PMC article.

10

Molecular determinants of pro-arrhythmia proclivity of d- and l-sotalol via a multi-scale modeling pipeline.

DeMarco KR, Yang PC, Singh V, Furutani K, Dawson JRD, Jeng MT, Fettinger JC, Bekker S, Ngo VA, Noskov SY, Yarov-Yarovoy V, Sack JT, Wulff H, Clancy CE, Vorobyov I. DeMarco KR, et al. J Mol Cell Cardiol. 2021 Sep;158:163-177. doi: 10.1016/j.yjmcc.2021.05.015. Epub 2021 May 29. J Mol Cell Cardiol. 2021. PMID: 34062207 Free PMC article.

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