Gradinaru V - Search Results

1

Machine learning-guided channelrhodopsin engineering enables minimally invasive optogenetics.

Bedbrook CN, Yang KK, Robinson JE, Mackey ED, Gradinaru V, Arnold FH. Bedbrook CN, et al. Among authors: gradinaru v. Nat Methods. 2019 Nov;16(11):1176-1184. doi: 10.1038/s41592-019-0583-8. Epub 2019 Oct 14. Nat Methods. 2019. PMID: 31611694 Free PMC article.

2

Directed evolution of a far-red fluorescent rhodopsin.

McIsaac RS, Engqvist MK, Wannier T, Rosenthal AZ, Herwig L, Flytzanis NC, Imasheva ES, Lanyi JK, Balashov SP, Gradinaru V, Arnold FH. McIsaac RS, et al. Among authors: gradinaru v. Proc Natl Acad Sci U S A. 2014 Sep 9;111(36):13034-9. doi: 10.1073/pnas.1413987111. Epub 2014 Aug 25. Proc Natl Acad Sci U S A. 2014. PMID: 25157169 Free PMC article.

3

Archaerhodopsin variants with enhanced voltage-sensitive fluorescence in mammalian and Caenorhabditis elegans neurons.

Flytzanis NC, Bedbrook CN, Chiu H, Engqvist MK, Xiao C, Chan KY, Sternberg PW, Arnold FH, Gradinaru V. Flytzanis NC, et al. Among authors: gradinaru v. Nat Commun. 2014 Sep 15;5:4894. doi: 10.1038/ncomms5894. Nat Commun. 2014. PMID: 25222271 Free PMC article.

4

Genetically Encoded Spy Peptide Fusion System to Detect Plasma Membrane-Localized Proteins In Vivo.

Bedbrook CN, Kato M, Ravindra Kumar S, Lakshmanan A, Nath RD, Sun F, Sternberg PW, Arnold FH, Gradinaru V. Bedbrook CN, et al. Among authors: gradinaru v. Chem Biol. 2015 Aug 20;22(8):1108-21. doi: 10.1016/j.chembiol.2015.06.020. Epub 2015 Jul 23. Chem Biol. 2015. PMID: 26211362 Free PMC article.

5

Neuroscience: Fluorescent boost for voltage sensors.

Gradinaru V, Flytzanis NC. Gradinaru V, et al. Nature. 2016 Jan 28;529(7587):469-70. doi: 10.1038/529469a. Nature. 2016. PMID: 26819038 No abstract available.

6

Cre-dependent selection yields AAV variants for widespread gene transfer to the adult brain.

Deverman BE, Pravdo PL, Simpson BP, Kumar SR, Chan KY, Banerjee A, Wu WL, Yang B, Huber N, Pasca SP, Gradinaru V. Deverman BE, et al. Among authors: gradinaru v. Nat Biotechnol. 2016 Feb;34(2):204-9. doi: 10.1038/nbt.3440. Epub 2016 Feb 1. Nat Biotechnol. 2016. PMID: 26829320 Free PMC article.

7

Directed Evolution of a Bright Near-Infrared Fluorescent Rhodopsin Using a Synthetic Chromophore.

Herwig L, Rice AJ, Bedbrook CN, Zhang RK, Lignell A, Cahn JKB, Renata H, Dodani SC, Cho I, Cai L, Gradinaru V, Arnold FH. Herwig L, et al. Among authors: gradinaru v. Cell Chem Biol. 2017 Mar 16;24(3):415-425. doi: 10.1016/j.chembiol.2017.02.008. Epub 2017 Mar 2. Cell Chem Biol. 2017. PMID: 28262559 Free PMC article.

8

Structure-guided SCHEMA recombination generates diverse chimeric channelrhodopsins.

Bedbrook CN, Rice AJ, Yang KK, Ding X, Chen S, LeProust EM, Gradinaru V, Arnold FH. Bedbrook CN, et al. Among authors: gradinaru v. Proc Natl Acad Sci U S A. 2017 Mar 28;114(13):E2624-E2633. doi: 10.1073/pnas.1700269114. Epub 2017 Mar 10. Proc Natl Acad Sci U S A. 2017. PMID: 28283661 Free PMC article.

9

Dorsal Raphe Dopamine Neurons Modulate Arousal and Promote Wakefulness by Salient Stimuli.

Cho JR, Treweek JB, Robinson JE, Xiao C, Bremner LR, Greenbaum A, Gradinaru V. Cho JR, et al. Among authors: gradinaru v. Neuron. 2017 Jun 21;94(6):1205-1219.e8. doi: 10.1016/j.neuron.2017.05.020. Epub 2017 Jun 8. Neuron. 2017. PMID: 28602690 Free article.

10

Dopaminergic dysfunction in neurodevelopmental disorders: recent advances and synergistic technologies to aid basic research.

Robinson JE, Gradinaru V. Robinson JE, et al. Among authors: gradinaru v. Curr Opin Neurobiol. 2018 Feb;48:17-29. doi: 10.1016/j.conb.2017.08.003. Epub 2017 Aug 30. Curr Opin Neurobiol. 2018. PMID: 28850815 Free PMC article. Review.

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