Fairlie WD - Search Results

1

A small molecule interacts with VDAC2 to block mouse BAK-driven apoptosis.

van Delft MF, Chappaz S, Khakham Y, Bui CT, Debrincat MA, Lowes KN, Brouwer JM, Grohmann C, Sharp PP, Dagley LF, Li L, McArthur K, Luo MX, Chin HS, Fairlie WD, Lee EF, Segal D, Duflocq S, Lessene R, Bernard S, Peilleron L, Nguyen T, Miles C, Wan SS, Lane RM, Wardak A, Lackovic K, Colman PM, Sandow JJ, Webb AI, Czabotar PE, Dewson G, Watson KG, Huang DCS, Lessene G, Kile BT. van Delft MF, et al. Among authors: fairlie wd. Nat Chem Biol. 2019 Nov;15(11):1057-1066. doi: 10.1038/s41589-019-0365-8. Epub 2019 Oct 7. Nat Chem Biol. 2019. PMID: 31591564

2

CED-4 forms a 2 : 2 heterotetrameric complex with CED-9 until specifically displaced by EGL-1 or CED-13.

Fairlie WD, Perugini MA, Kvansakul M, Chen L, Huang DC, Colman PM. Fairlie WD, et al. Cell Death Differ. 2006 Mar;13(3):426-34. doi: 10.1038/sj.cdd.4401762. Cell Death Differ. 2006. PMID: 16167070

3

Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak.

Willis SN, Fletcher JI, Kaufmann T, van Delft MF, Chen L, Czabotar PE, Ierino H, Lee EF, Fairlie WD, Bouillet P, Strasser A, Kluck RM, Adams JM, Huang DC. Willis SN, et al. Among authors: fairlie wd. Science. 2007 Feb 9;315(5813):856-9. doi: 10.1126/science.1133289. Science. 2007. PMID: 17289999

4

A structural viral mimic of prosurvival Bcl-2: a pivotal role for sequestering proapoptotic Bax and Bak.

Kvansakul M, van Delft MF, Lee EF, Gulbis JM, Fairlie WD, Huang DC, Colman PM. Kvansakul M, et al. Among authors: fairlie wd. Mol Cell. 2007 Mar 23;25(6):933-42. doi: 10.1016/j.molcel.2007.02.004. Mol Cell. 2007. PMID: 17386268 Free article.

5

Structural insights into the degradation of Mcl-1 induced by BH3 domains.

Czabotar PE, Lee EF, van Delft MF, Day CL, Smith BJ, Huang DC, Fairlie WD, Hinds MG, Colman PM. Czabotar PE, et al. Among authors: fairlie wd. Proc Natl Acad Sci U S A. 2007 Apr 10;104(15):6217-22. doi: 10.1073/pnas.0701297104. Epub 2007 Mar 27. Proc Natl Acad Sci U S A. 2007. PMID: 17389404 Free PMC article.

6

Crystal structure of ABT-737 complexed with Bcl-xL: implications for selectivity of antagonists of the Bcl-2 family.

Lee EF, Czabotar PE, Smith BJ, Deshayes K, Zobel K, Colman PM, Fairlie WD. Lee EF, et al. Among authors: fairlie wd. Cell Death Differ. 2007 Sep;14(9):1711-3. doi: 10.1038/sj.cdd.4402178. Epub 2007 Jun 15. Cell Death Differ. 2007. PMID: 17572662 No abstract available.

7

A novel BH3 ligand that selectively targets Mcl-1 reveals that apoptosis can proceed without Mcl-1 degradation.

Lee EF, Czabotar PE, van Delft MF, Michalak EM, Boyle MJ, Willis SN, Puthalakath H, Bouillet P, Colman PM, Huang DC, Fairlie WD. Lee EF, et al. Among authors: fairlie wd. J Cell Biol. 2008 Jan 28;180(2):341-55. doi: 10.1083/jcb.200708096. Epub 2008 Jan 21. J Cell Biol. 2008. PMID: 18209102 Free PMC article.

8

Vaccinia virus anti-apoptotic F1L is a novel Bcl-2-like domain-swapped dimer that binds a highly selective subset of BH3-containing death ligands.

Kvansakul M, Yang H, Fairlie WD, Czabotar PE, Fischer SF, Perugini MA, Huang DC, Colman PM. Kvansakul M, et al. Among authors: fairlie wd. Cell Death Differ. 2008 Oct;15(10):1564-71. doi: 10.1038/cdd.2008.83. Epub 2008 Jun 13. Cell Death Differ. 2008. PMID: 18551131

9

EGL-1 BH3 mutants reveal the importance of protein levels and target affinity for cell-killing potency.

Lee EF, Chen L, Yang H, Colman PM, Huang DC, Fairlie WD. Lee EF, et al. Among authors: fairlie wd. Cell Death Differ. 2008 Oct;15(10):1609-18. doi: 10.1038/cdd.2008.86. Epub 2008 Jun 20. Cell Death Differ. 2008. PMID: 18566606

10

Structure of the BH3 domains from the p53-inducible BH3-only proteins Noxa and Puma in complex with Mcl-1.

Day CL, Smits C, Fan FC, Lee EF, Fairlie WD, Hinds MG. Day CL, et al. Among authors: fairlie wd. J Mol Biol. 2008 Jul 25;380(5):958-71. doi: 10.1016/j.jmb.2008.05.071. Epub 2008 Jun 4. J Mol Biol. 2008. PMID: 18589438

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