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A Replication-Defective Human Cytomegalovirus Vaccine Elicits Humoral Immune Responses Analogous to Those with Natural Infection.
Liu Y, Freed DC, Li L, Tang A, Li F, Murray EM, Adler SP, McVoy MA, Rupp RE, Barrett D, Ye X, Zhang N, Beck K, Culp T, Das R, Song L, Vora K, Zhu H, Wang D, Espeseth AS, An Z, Musey L, Fu TM. Liu Y, et al. Among authors: wang d. J Virol. 2019 Nov 13;93(23):e00747-19. doi: 10.1128/JVI.00747-19. Print 2019 Dec 1. J Virol. 2019. PMID: 31511385 Free PMC article. Clinical Trial.
We have previously described a replication-defective virus vaccine based on strain AD169 (D. Wang, D. C. Freed, X. He, F. Li, et al., Sci Transl Med 8:362ra145, 2016, https://doi.org/10.1126/scitranslmed.aaf9387). ...
We have previously described a replication-defective virus vaccine based on strain AD169 (D. Wang, D. C. Freed, X. He, …
Pentameric complex of viral glycoprotein H is the primary target for potent neutralization by a human cytomegalovirus vaccine.
Freed DC, Tang Q, Tang A, Li F, He X, Huang Z, Meng W, Xia L, Finnefrock AC, Durr E, Espeseth AS, Casimiro DR, Zhang N, Shiver JW, Wang D, An Z, Fu TM. Freed DC, et al. Among authors: wang d. Proc Natl Acad Sci U S A. 2013 Dec 17;110(51):E4997-5005. doi: 10.1073/pnas.1316517110. Epub 2013 Dec 2. Proc Natl Acad Sci U S A. 2013. PMID: 24297878 Free PMC article.
Soluble Human Cytomegalovirus gH/gL/pUL128-131 Pentameric Complex, but Not gH/gL, Inhibits Viral Entry to Epithelial Cells and Presents Dominant Native Neutralizing Epitopes.
Loughney JW, Rustandi RR, Wang D, Troutman MC, Dick LW Jr, Li G, Liu Z, Li F, Freed DC, Price CE, Hoang VM, Culp TD, DePhillips PA, Fu TM, Ha S. Loughney JW, et al. Among authors: wang d. J Biol Chem. 2015 Jun 26;290(26):15985-95. doi: 10.1074/jbc.M115.652230. Epub 2015 May 6. J Biol Chem. 2015. PMID: 25947373 Free PMC article.
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