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Page 1
The translation of non-canonical open reading frames controls mucosal immunity.
Jackson R, Kroehling L, Khitun A, Bailis W, Jarret A, York AG, Khan OM, Brewer JR, Skadow MH, Duizer C, Harman CCD, Chang L, Bielecki P, Solis AG, Steach HR, Slavoff S, Flavell RA. Jackson R, et al. Among authors: steach hr. Nature. 2018 Dec;564(7736):434-438. doi: 10.1038/s41586-018-0794-7. Epub 2018 Dec 12. Nature. 2018. PMID: 30542152 Free PMC article.
Distinct modes of mitochondrial metabolism uncouple T cell differentiation and function.
Bailis W, Shyer JA, Zhao J, Canaveras JCG, Al Khazal FJ, Qu R, Steach HR, Bielecki P, Khan O, Jackson R, Kluger Y, Maher LJ 3rd, Rabinowitz J, Craft J, Flavell RA. Bailis W, et al. Among authors: steach hr. Nature. 2019 Jul;571(7765):403-407. doi: 10.1038/s41586-019-1311-3. Epub 2019 Jun 19. Nature. 2019. PMID: 31217581 Free PMC article.
Mechanosensation of cyclical force by PIEZO1 is essential for innate immunity.
Solis AG, Bielecki P, Steach HR, Sharma L, Harman CCD, Yun S, de Zoete MR, Warnock JN, To SDF, York AG, Mack M, Schwartz MA, Dela Cruz CS, Palm NW, Jackson R, Flavell RA. Solis AG, et al. Among authors: steach hr. Nature. 2019 Sep;573(7772):69-74. doi: 10.1038/s41586-019-1485-8. Epub 2019 Aug 21. Nature. 2019. PMID: 31435009 Free PMC article.
An in vivo screen of noncoding loci reveals that Daedalus is a gatekeeper of an Ikaros-dependent checkpoint during haematopoiesis.
Harman CCD, Bailis W, Zhao J, Hill L, Qu R, Jackson RP, Shyer JA, Steach HR, Kluger Y, Goff LA, Rinn JL, Williams A, Henao-Mejia J, Flavell RA. Harman CCD, et al. Among authors: steach hr. Proc Natl Acad Sci U S A. 2021 Jan 19;118(3):e1918062118. doi: 10.1073/pnas.1918062118. Proc Natl Acad Sci U S A. 2021. PMID: 33446502 Free PMC article.
Skin-resident innate lymphoid cells converge on a pathogenic effector state.
Bielecki P, Riesenfeld SJ, Hütter JC, Torlai Triglia E, Kowalczyk MS, Ricardo-Gonzalez RR, Lian M, Amezcua Vesely MC, Kroehling L, Xu H, Slyper M, Muus C, Ludwig LS, Christian E, Tao L, Kedaigle AJ, Steach HR, York AG, Skadow MH, Yaghoubi P, Dionne D, Jarret A, McGee HM, Porter CBM, Licona-Limón P, Bailis W, Jackson R, Gagliani N, Gasteiger G, Locksley RM, Regev A, Flavell RA. Bielecki P, et al. Among authors: steach hr. Nature. 2021 Apr;592(7852):128-132. doi: 10.1038/s41586-021-03188-w. Epub 2021 Feb 3. Nature. 2021. PMID: 33536623 Free PMC article.
Inflammasome activation in infected macrophages drives COVID-19 pathology.
Sefik E, Qu R, Junqueira C, Kaffe E, Mirza H, Zhao J, Brewer JR, Han A, Steach HR, Israelow B, Blackburn HN, Velazquez SE, Chen YG, Halene S, Iwasaki A, Meffre E, Nussenzweig M, Lieberman J, Wilen CB, Kluger Y, Flavell RA. Sefik E, et al. Among authors: steach hr. Nature. 2022 Jun;606(7914):585-593. doi: 10.1038/s41586-022-04802-1. Epub 2022 Apr 28. Nature. 2022. PMID: 35483404 Free PMC article.
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