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P-selectin glycoprotein ligand regulates the interaction of multiple myeloma cells with the bone marrow microenvironment.
Azab AK, Quang P, Azab F, Pitsillides C, Thompson B, Chonghaile T, Patton JT, Maiso P, Monrose V, Sacco A, Ngo HT, Flores LM, Lin CP, Magnani JL, Kung AL, Letai A, Carrasco R, Roccaro AM, Ghobrial IM. Azab AK, et al. Among authors: magnani jl. Blood. 2012 Feb 9;119(6):1468-78. doi: 10.1182/blood-2011-07-368050. Epub 2011 Nov 16. Blood. 2012. PMID: 22096244 Free PMC article.
E-selectin ligands recognised by HECA452 induce drug resistance in myeloma, which is overcome by the E-selectin antagonist, GMI-1271.
Natoni A, Smith TAG, Keane N, McEllistrim C, Connolly C, Jha A, Andrulis M, Ellert E, Raab MS, Glavey SV, Kirkham-McCarthy L, Kumar SK, Locatelli-Hoops SC, Oliva I, Fogler WE, Magnani JL, O'Dwyer ME. Natoni A, et al. Among authors: magnani jl. Leukemia. 2017 Dec;31(12):2642-2651. doi: 10.1038/leu.2017.123. Epub 2017 Apr 25. Leukemia. 2017. PMID: 28439107 Free PMC article.
P- and E-selectin receptor antagonism prevents human leukocyte adhesion to activated porcine endothelial monolayers and attenuates porcine endothelial damage.
Laird CT, Hassanein W, O'Neill NA, French BM, Cheng X, Fogler WE, Magnani JL, Parsell D, Cimeno A, Phelps CJ, Ayares D, Burdorf L, Azimzadeh AM, Pierson RN 3rd. Laird CT, et al. Among authors: magnani jl. Xenotransplantation. 2018 Mar;25(2):e12381. doi: 10.1111/xen.12381. Epub 2018 Jan 23. Xenotransplantation. 2018. PMID: 29359469 Free PMC article.
E-selectin inhibitor is superior to low-molecular-weight heparin for the treatment of experimental venous thrombosis.
Myers DD Jr, Ning J, Lester P, Adili R, Hawley A, Durham L, Dunivant V, Reynolds G, Crego K, Sood S, Sigler R, Fogler WE, Magnani JL, Holinstat M, Wakefield T. Myers DD Jr, et al. Among authors: magnani jl. J Vasc Surg Venous Lymphat Disord. 2022 Jan;10(1):211-220. doi: 10.1016/j.jvsv.2020.12.086. Epub 2021 Apr 17. J Vasc Surg Venous Lymphat Disord. 2022. PMID: 33872819
A new way to treat proximal deep venous thrombosis using E-selectin inhibition.
Myers D Jr, Lester P, Adili R, Hawley A, Durham L, Dunivant V, Reynolds G, Crego K, Zimmerman Z, Sood S, Sigler R, Fogler W, Magnani J, Holinstat M, Wakefield T. Myers D Jr, et al. J Vasc Surg Venous Lymphat Disord. 2020 Mar;8(2):268-278. doi: 10.1016/j.jvsv.2019.08.016. J Vasc Surg Venous Lymphat Disord. 2020. PMID: 32067728 Free PMC article.
101 results